Comparison of hormone profile and systemic inflammation in patients presenting with sexual dysfunction: Which is important

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dc.contributor.authorDemirci, Aykut
dc.contributor.authorÖzgür, Berat Cem
dc.contributor.authorTuncer, Sibel Çiğdem
dc.date.accessioned2021-02-02T07:28:23Z
dc.date.available2021-02-02T07:28:23Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description*Demirci, Aykut ( Aksaray, Yazar ) *Tuncer, Sibel Çiğdem ( Aksaray, Yazar )
dc.description.abstractIntroduction: Erectile dysfunction (ED) is the inability to achieve or maintain erection sufficient for satisfactory sexual performance. Although the definition is well known, there are controversial issues about the effects of hormones and inflammation on ED. Objectives: We aimed to compare the clinical value of the hormonal and inflammation parameters in sexual dysfunction. Materials and methods: A total of 152 patients diagnosed with erectile dysfunction between September 2018 and March 2019 and 101 healthy males were included in this prospective study as case group and control group, respectively. The 152 patients were divided into three groups based on their total International Index of Erectile Function (IIEF) scores: (I) severe ED, (II) mild-moderate ED and (III) mild ED. All groups were compared in terms of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and total testosterone (TT), estradiol, prolactin, testosterone-to-estradiol ratio and 25 (OH) vitamin D. Results: Patient and control groups differed significantly in term of NLR, PLR, prolactin and vitamin D (p < 0.001, p = 0.004, p = 0.002, p < 0.001, p < 0.001, respectively). NLR was more significant in determining the severity of ED (p < 0.001). It was observed that libido score (the total score of IIEF items #11 and #12) was negatively associated with prolactin and NLR (p < 0.001, p = 0.023, respectively), was positively associated with vitamin D and TT (p < 0.001, p = 0.02, respectively), and was lower in severe ED patients. Conclusions: Although more clinical studies are needed, we think that our findings may be useful on these controversial issues of ED.
dc.identifier.doi10.1016/j.androl.2020.04.002
dc.identifier.issn1698-031X
dc.identifier.issue-en_US
dc.identifier.pmid32888890
dc.identifier.scopusqualityQ3
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.androl.2020.04.002
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7708
dc.identifier.volume-en_US
dc.identifier.wosWOS:000699900300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdiciones Doyma, S.L.
dc.relation.ispartofRevista Internacional de Andrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectErectile Dysfunction
dc.subjectHormone
dc.subjectLibido
dc.subjectNeutrophil Lymphocyte Ratio
dc.subjectPlatelet Lymphocyte Ratio
dc.titleComparison of hormone profile and systemic inflammation in patients presenting with sexual dysfunction: Which is important
dc.title.alternativeComparación de perfil hormonal e inflamación sistémica en pacientes con disfunción sexual: ¿por qué es importante
dc.typeArticle

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