The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death
| dc.contributor.author | Kankılıç, Nazım Abdülkadir | |
| dc.contributor.author | Şimşek, Hasan | |
| dc.contributor.author | Akaras, Nurhan | |
| dc.contributor.author | Gür, Cihan | |
| dc.contributor.author | Küçükler, Sefa | |
| dc.contributor.author | Gencer, Selman | |
| dc.contributor.author | Kandemir, Fatih Mehmet | |
| dc.date.accessioned | 2024-07-02T05:44:49Z | |
| dc.date.available | 2024-07-02T05:44:49Z | |
| dc.date.issued | 2024 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is believed to be oxidative stress. Chrysin is a compound found actively in honey and many plant species and stands out with its antioxidant properties. The present study aimed to determine the ameliorative effects of chrysin in bortezomib-induced nephrotoxicity. Material-method: Thirty-five male Wistar rats were divided into control, BTZ, CHR, BTZ + CHR25, and BTZ + CHR50. Biochemical, molecular, Western blot, and histological methods analyzed renal function indicators, oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and damage pathways. Results: Chrysin decreased oxidative stress by reducing oxidants (MDA) and increasing antioxidants (SOD, CAT, Gpx, GSH, Nrf-2, HO-1, NQO1). Chrysin reduced endoplasmic reticulum stress by decreasing ATF-6, PERK, IRE1, and GRP-78 levels. Chrysin reduced inflammation damage by inhibiting the NF-?B pathway. Chrysin exhibited protective properties against apoptotic damage by decreasing Bax and Caspase-3 levels and increasing Bcl-2 levels. In addition, chrysin improved renal function and structural integrity and exhibited healing properties against toxic damage in tissue structure. Conclusion: Overall, chrysin exhibited an ameliorative effect against bortezomib-induced nephrotoxicity. | |
| dc.identifier.doi | 10.1016/j.fct.2024.114791 | |
| dc.identifier.issn | 0278-6915 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https:/dx.doi.org/10.1016/j.fct.2024.114791 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/12006 | |
| dc.identifier.volume | 190 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Ltd | |
| dc.relation.ispartof | Food and Chemical Toxicology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Apoptosis | |
| dc.subject | Bortezomib | |
| dc.subject | Chrysin | |
| dc.subject | Inflammation | |
| dc.subject | Nephrotoxicity | |
| dc.subject | Oxidative stres | |
| dc.title | The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death | |
| dc.type | Article |
