Galectin-3 levels in school aged children with autism spectrum disorder
| dc.authorid | 0000-0001-7909-9944 | |
| dc.contributor.author | Artık, Abdülbaki | |
| dc.contributor.author | Kocaman, Orhan | |
| dc.contributor.author | Kara, Halil | |
| dc.contributor.author | Tuncer, Sibel Çiğdem | |
| dc.date.accessioned | 2023-01-16T05:33:15Z | |
| dc.date.available | 2023-01-16T05:33:15Z | |
| dc.date.issued | 2023 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may be central to the ethiopathogenesis of ASD. Method: The current study consisted of 33 psychotropic medication-naive children with ASD and 32 control subjects. The Schedule for Affective Disorders and Schizophrenia for School-Aged Children, Present and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5) was used to screen healthy controls for psychiatric disorders by a psychiatrist after a physical examination by a pediatrician. The clinical severity of the ASD symptoms has been assessed by the Childhood Autism Rating Scale (CARS). Venous blood samples were collected and serum galectin-3 levels were measured. Results: When the ASD and control groups are compared, the mean galectin-3 level is 417.77 (SD = 200.20) in the ASD group and 243.08 (SD = 64.65) in the control group, and there is a statistically significant difference between the groups (p < 0.001). When examining whether there is a correlation between galectin-3 levels and CARS total scores, no statistically significant correlation was found between them (r = 0.015, p = 0.933). Discussion: In this study, we examined whether serum galectin-3 levels have a relation with ASD in childhood or not. Our findings have indicated that the children with ASD have higher serum galectin-3 levels compared to the controls. However, no significant relationship has been found between serum galectin-3 levels and ASD symptom severity. | |
| dc.identifier.doi | 10.1080/20473869.2022.2150035 | |
| dc.identifier.endpage | - | en_US |
| dc.identifier.issn | 2047-3869 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.pmid | 37547549 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | - | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1080/20473869.2022.2150035 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/9920 | |
| dc.identifier.volume | - | en_US |
| dc.identifier.wos | WOS:000912334500001 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.relation.ispartof | International Journal of Developmental Disabilities | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | ADHD | |
| dc.subject | ASD | |
| dc.subject | CARS | |
| dc.subject | Etiology of ASD | |
| dc.subject | Galectin-3 Levels | |
| dc.subject | Inflammatıon | |
| dc.subject | Neurodevelopmental Disorders | |
| dc.subject | Serum Markers | |
| dc.title | Galectin-3 levels in school aged children with autism spectrum disorder | |
| dc.type | Article |
