Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

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dc.authoridALGUL, OZTEKIN -- 0000-0001-5685-7511; , deryanur -- 0000-0002-9115-136X; GULCIN, Ilhami -- 0000-0001-5993-1668
dc.contributor.authorBurmaoğlu, Serdar
dc.contributor.authorYılmaz, Ali Osman
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAlgül, Öztekin
dc.contributor.authorKılıç, Deryanur
dc.contributor.authorGülçin, İlhami
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:32Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:32Z
dc.date.issued2018
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractA series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [14Z554]
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant number: 14Z554
dc.identifier.doi10.1002/ardp.201700314
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue2en_US
dc.identifier.pmid29323749
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/ardp.201700314
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5629
dc.identifier.volume351en_US
dc.identifier.wosWOS:000423801700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofARCHIV DER PHARMAZIE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject-Glycosidase
dc.subjectAcetylcholinesterase
dc.subjectButyrylcholinesterase
dc.subjectCarbonic Anhydrase
dc.subjectPhloroglucinol Derivatives
dc.titleSynthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity
dc.typeArticle

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