Propolis protects endotoxin induced acute lung and liver inflammation through attenuating inflammatory responses and oxidative stress

dc.authoridDincer, Murat -- 0000-0001-7110-4155
dc.contributor.authorYangi, Berat
dc.contributor.authorÜstüner, Mehmet Cengiz
dc.contributor.authorDinçer, Murat
dc.contributor.authorÖzbayer, Cansu
dc.contributor.authorTekin, Neslihan
dc.contributor.authorÜstüner, Derya
dc.contributor.authorÇolak, Emine
dc.contributor.authorKolaç, Umut Kerem
dc.contributor.authorEntok, Emre
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:15Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:15Z
dc.date.issued2018
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractPropolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced inflammation in rats. Forty-two, 3- to 4-month-old male Sprague Dawley rats were used in six groups. LPS (1mg/kg) was administered intraperitoneally to rats in inflammation, inflammation + propolis30, and inflammation+propolis90 groups. Thirty milligram/kilogram and 90mg/kg of propolis were given orally 24 h after LPS injection. After the determination of the inflammation in lung and liver tissues by F-18-fluoro-deoxy-d-glucose-positron emission tomography ((18)FDG-PET), samples were collected. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO), and DNA fragmentation were determined. The decrease of MDA levels in inflammation + propolis30 and inflammation + propolis90 groups was determined compared to the inflammation group in lung and liver tissues. The increase of SOD% inhibition in inflammation + propolis90 group was determined in liver, lung, and hemolysate compared to the inflammation group. Increased CAT activities in inflammation + propolis30 and inflammation + propolis90 groups were observed in liver tissue and hemolysate compared to inflammation group. In lung tissue, NO levels were lower in inflammation group compared to the control group, but DNA fragmentation levels were higher. F-18-FDG uptake of tissues in inflammation + propolis30 and inflammation + propolis90 groups was decreased compared to the inflammation group. In conclusion, the data of this study indicate that the propolis application may serve as a potential approach for treating inflammatory diseases through the effect of reducing inflammation and free oxygen radical production.
dc.identifier.doi10.1089/jmf.2017.0151
dc.identifier.endpage1105en_US
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue11en_US
dc.identifier.pmid29719160
dc.identifier.scopusqualityQ2
dc.identifier.startpage1096en_US
dc.identifier.urihttps://doi.org/10.1089/jmf.2017.0151
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4332
dc.identifier.volume21en_US
dc.identifier.wosWOS:000431372400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert
dc.relation.ispartofJournal of Medicinal Food
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject(18)FDG-PET
dc.subjectAntioxidant Enzymes
dc.subjectDNA Fragmentation
dc.subjectInflammation
dc.subjectPropolis
dc.titlePropolis protects endotoxin induced acute lung and liver inflammation through attenuating inflammatory responses and oxidative stress
dc.typeArticle

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