ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals
| dc.contributor.author | Dinçel, Güngör Çağdaş | |
| dc.contributor.author | Yavuz, Orhan | |
| dc.contributor.author | Yıldirım, Serkan | |
| dc.contributor.author | Al-Olayan, Ebtesam M. | |
| dc.date.accessioned | 2024-04-19T08:33:30Z | |
| dc.date.available | 2024-04-19T08:33:30Z | |
| dc.date.issued | 2023 | |
| dc.department | Veteriner Fakültesi | |
| dc.description.abstract | This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps). ADAMTS-13, HMGB1, glutathione reductase (GR), copper/zinc superoxide dismutase (Cu/Zn SOD), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression levels were studied. The study found that ADAMTS-13 (P < 0.005), HMGB1 (P < 0.005), GR (P < 0.005), Cu/Zn SOD (P < 0.005), and 8-OHdG (P < 0.005) levels were significantly higher in T. multiceps (c. cerebralis)-infected animals compared to healthy control animals. This study's most important finding was that HMGB1 up-regulation in neurons, endothelial cells, and glial cells can directly cause brain parenchymal destruction and that HMGB1-mediated oxidative stress plays a crucial role in the neuropathogenesis of coenurosis. The results also showed that increased levels of ADAMTS-13 may play a pivotal role in regulating and protecting the blood–brain barrier integrity and neuroprotection. These findings also suggest that ADAMTS-13 and HMGB1 compete in the prevention or formation of microthrombi, which was regarded as a remarkable finding. ADAMTS-13 and HMGB1 are valuable biomarkers for disease risk assessment, estimating host neuropathy following T. multiceps (c. cerebralis) exposure, and providing a new therapeutic target. This is the first study to show that HMGB1 and ADAMTS-13 are expressed in reactive cells and are associated with neuroimmunopathology in coenurosis. | |
| dc.identifier.doi | 10.1038/s41598-023-44376-0 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.pmid | 37863934 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https:/dx.doi.org10.1038/s41598-023-44376-0 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/11657 | |
| dc.identifier.volume | 13 | en_US |
| dc.identifier.wos | WOS:001087596300058 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Nature Research | |
| dc.relation.ispartof | Scientific Reports | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ADAMTS13 Protein | |
| dc.subject | Animals | |
| dc.subject | Cestode Infections; Copper; | |
| dc.subject | Cestode Infections | |
| dc.subject | Copper | |
| dc.title | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals | |
| dc.type | Article |
