Prevention of urinary infection through the incorporation of silver-ricinoleic acid-polystyrene nanoparticles on the catheter surface

Basit Öğe Kaydı
dc.contributor.authorKoç, Hazal
dc.contributor.authorKılıçay, Ebru
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorHazer, Baki
dc.contributor.authorDenkbaş, Emir B.
dc.date.accessioned2021-05-18T11:47:40Z
dc.date.available2021-05-18T11:47:40Z
dc.date.issued2021
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description*Karahaliloğlu, Zeynep ( Aksaray, Yazar )
dc.description.abstractNosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline hydrochloride (TCH) attached Ag nanoparticles embedded PolyRicinoleic acid-Polystyrene Nanoparticles (PU-TCH-AgNPs-PRici-PS NPs) and the influence on antimicrobial and antibiofilm activity of urinary catheters infected by Escherichia coli and Staphylococcus aureus. For this purpose, AgNPs embedded PRici graft PS graft copolymers (AgNPs-PRici-g-PS) were synthesized via free radical polymerization and characterized by FTIR, HNMR and DSC. AgNPs-PRici-PS NPs were prepared and optimized by the different parameters and the optimized size of nanoparticle was found as about 150 +/- 1 nm. The characterization of the nanoparticles and the morphological evaluation were carried out by FTIR and SEM. Short term stability of nanoparticles was realised at 4 degrees C for 30 days. In vitro release profiles of TCH and Ag NPs were also investigated. The formation of biofilm on PU modified TCH-Ag NPs-PRici-PS NPs, was evaluated and the biocompatibility test of the nanoparticles was realized via the mouse fibroblast (L929) and mouse urinary bladder cells (G/G An1). This is the first time that TCH-AgNPs-PRici-PS NPs used in the modification of PU catheter demonstrated high antimicrobial and antibiofilm activities against the urinary tract infection.
dc.identifier.doi10.1177/0885328220983552
dc.identifier.endpage-en_US
dc.identifier.issue-en_US
dc.identifier.pmid33530824
dc.identifier.scopusqualityQ2
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1177/0885328220983552
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7961
dc.identifier.volume-en_US
dc.identifier.wosWOS:000630807500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKaratekin University
dc.relation.ispartofJournal of Biomaterials Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrinary Catheter
dc.subjectTetracycline Hydrochloride
dc.subjectSilver Nanoparticle
dc.subjectPolystyrene
dc.subjectRicinoleic Acid
dc.titlePrevention of urinary infection through the incorporation of silver-ricinoleic acid-polystyrene nanoparticles on the catheter surface
dc.typeArticle

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