Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material

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dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorKılıçay, Ebru
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:07Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:07Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractAntimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhibition zone increased from 2 +/- 0.4 to 7 +/- 0.1mm for Escherichia coli, as well as from 2.5 +/- 0.2 to 6 +/- 0.4mm for Staphylococcus aureus while CHTS/SS/100nZnO compared to CHT/SS/0.01LA. The results not only showed excellent inhibition against Gram-positive and Gram-negative bacterial growth but also revealed improved proliferation and extended viability for HaCaT cells.
dc.description.sponsorshipBulent Ecevit University Research Fund [BEU-2015-33496813-01]
dc.description.sponsorshipThis work was financially supported by the Bulent Ecevit University Research Fund (BEU-2015-33496813-01).
dc.identifier.doi10.1080/21691401.2016.1203796
dc.identifier.endpage1185en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue6en_US
dc.identifier.pmid27396677
dc.identifier.scopusqualityQ1
dc.identifier.startpage1172en_US
dc.identifier.urihttps://doi.org/10.1080/21691401.2016.1203796
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5790
dc.identifier.volume45en_US
dc.identifier.wosWOS:000404022000015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArtificial Cells Nanomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChitosan
dc.subjectLauric Acid
dc.subjectSilk Sericin
dc.subjectWound Dressing
dc.subjectZinc Oxide Nanoparticles
dc.titleAntibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material
dc.typeArticle

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