Allergy-specific phenome-wide association study for ımmunogenes in Turkish children

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dc.authoridOzgul, Riza Koksal -- 0000-0002-0283-635X; Polimanti, Renato -- 0000-0003-0745-6046
dc.contributor.authorKaraca, Şefayet
dc.contributor.authorCivelek, Ersoy
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorŞahiner, Ümit M.
dc.contributor.authorÖzgul, Rıza K.
dc.contributor.authorKocabaş, Can N.
dc.contributor.authorPolimanti, Renato
dc.contributor.authorSekerel, Bülent E.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:49Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:49Z
dc.date.issued2016
dc.departmentSağlık Bilimleri Fakültesi
dc.description.abstractTo dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests. Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age-and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)). IL4 rs2243250 was associated with increased FEV240 (Forced Expiratory Flow Volume after 240s of hypertonic saline inhalation; p = 4.81*10(-4)) and CD14 rs2569190 was associated with asthma diagnosis (p = 1.36*10(-3)). ADAM33 and IL4 appeared to play a role in the processes linked to allergic airway inflammation and lung function. Due to its association with wheezing and eczema comorbidity, ADAM33 may also be involved in the atopic march.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [SBAG-213S025]
dc.description.sponsorshipThis study was supported by a grant (SBAG-213S025) from the Scientific and Technological Research Council of Turkey (TUBITAK). The Authors are indebted to the field workers, those who collaborated in the participating centers, and all the parents and school staff who assisted in the surveys.
dc.identifier.doi10.1038/srep33152
dc.identifier.issn2045-2322
dc.identifier.pmid27624002
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/srep33152
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6089
dc.identifier.volume6en_US
dc.identifier.wosWOS:000383196100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAllergy-specific phenome-wide association study for ımmunogenes in Turkish children
dc.typeArticle

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