Some polyphenolic compounds as potential therapeutic agents in cervical cancer: the most recent advances and future prospects

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dc.contributor.authorTunca Şanlıer, Nazlı
dc.contributor.authorSaçıntı, Koray Görkem
dc.contributor.authorTürkoğlu, İnci
dc.contributor.authorŞanlıer, Nevin
dc.date.accessioned2024-09-25T06:22:18Z
dc.date.available2024-09-25T06:22:18Z
dc.date.issued2024
dc.departmentTıp Fakültesi
dc.description.abstractThe leading causes of cancer include gradual changes in regulatory proteins, dysregulated cell-signaling pathways, dysfunction of apoptosis, and oxidative stress. Consuming polyphenols from food sources has been proven to have strong connections with ameliorating specific physiological biomarkers along with other elements concerning cancer. Recent studies have focused on polyphenols' molecular mechanisms of action and anticancer and chemopreventive properties and effects in the treatment of different types of cancer. Polyphenols participate in the regulation of numerous cellular mechanisms alongside signaling pathways through their effects on inflammation, cellular proliferation, apoptosis, and partially via epigenetic alterations in cervical cancer. A number of animal models and cell and human studies have indicated the use of polyphenols to be safe and tolerable. Thus, it would be fair to state that, with their advantages vis-à-vis lack of toxicity, cost, and access, and with the positive clinical results, polyphenols have a potential to make a difference in cancer treatment. The present review examined the chemical and physical properties, analogs, metabolites, and mechanisms of physiological activities of various polyphenols and how they may affect the incidence rate and management of cervical cancer. Therefore, this review constitutes a starting point to examine the potential applications for cervical cancer.
dc.identifier.doi10.1093/nutrit/nuae126
dc.identifier.urihttps:/dx.doi.org/10.1093/nutrit/nuae126
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12459
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Academic
dc.relation.ispartofNutrition Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticancer Activity
dc.subjectCervical Cancer
dc.subjectPolyphenols
dc.titleSome polyphenolic compounds as potential therapeutic agents in cervical cancer: the most recent advances and future prospects
dc.typeArticle

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