Protective Effects of Baicalein and Bergenin Against Gentamicin-Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study

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dc.authorid0000-0001-9585-3169
dc.authorid0000-0003-2457-3367
dc.authorid0000-0002-8490-2479
dc.authorid0000-0002-8330-3095
dc.authorid0000-0003-2424-2269
dc.authorid0000-0001-8588-1035
dc.contributor.authorEkinci Akdemir, Fazile Nur
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorEraslan, Ersen
dc.contributor.authorGüler, Mustafa Can
dc.date.accessioned2025-07-17T07:09:06Z
dc.date.available2025-07-17T07:09:06Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractDrug-induced organ toxicity is a significant health concern, with gentamicin known for its effective antibacterial properties but also severe side effects, particularly cytotoxicity in liver and kidney tissues. This current study observed the preventive role of baicalein and bergenin against hepatic and renal injuries caused by gentamicin in rats. Methods: Thirty-two male Sprague Dawley rats were divided into four groups, namely, control, gentamicin (gentamicin 80 mg/kg/day), baicalein (gentamicin 80 mg/kg/day + baicalein 100 mg/kg/day) and bergenin (gentamicin 80 mg/kg/day + bergenin 100 mg/kg/day). Hepatotoxicity and nephrotoxicity were induced by giving gentamicin (80 mg/kg/day). We evaluated the biochemical markers, including alkaline phosphatase (ALP), urea, alanine transaminase (ALT), creatinine and aspartate transaminase (AST) levels, antioxidant enzymes, oxidative stress parameters and histopathological and immunohistochemical changes. Results: Gentamicin increased oxidative stress parameters and decreased antioxidant activity. The treatment with baicalein and bergenin significantly restored these markers. Conclusions: Baicalein and bergenin significantly mitigated gentamicin-induced hepatic and renal toxicity by restoring biochemical markers, reducing oxidative stress and enhancing antioxidant enzyme activity. Histopathological and immunohistochemical analyses confirmed the protective effects of both compounds against organ damage. No statistically significant differences were observed between the two drugs for these parameters. These results suggest their potential as therapeutic agents to prevent gentamicin-induced organ toxicity.
dc.identifier.doi10.1111/bcpt.14121
dc.identifier.issn17427835
dc.identifier.issue1
dc.identifier.pmid39726240
dc.identifier.scopus85213400783
dc.identifier.urihttps://dx.doi.org/10.1111/bcpt.14121
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13342
dc.identifier.volume136
dc.identifier.wosWOS:001388144900020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKandemir, Fatih Mehmet
dc.institutionauthorid0000-0002-8490-2479
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofBasic and Clinical Pharmacology and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBaicalein
dc.subjectBergenin
dc.subjectGentamicin
dc.subjectHepatic Injury
dc.subjectRenal Injury
dc.titleProtective Effects of Baicalein and Bergenin Against Gentamicin-Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study
dc.typeArticle

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