MXene-modified PMMA/chitosan composite e-skin scaffold: Bioelectronic and antibacterial assessment
| dc.contributor.author | Gürbüz, Berfin | |
| dc.contributor.author | Çiftçi, Fatih | |
| dc.contributor.author | Özarslan, Ali Can | |
| dc.contributor.author | Akyüz Yılmaz, Bahar | |
| dc.date.accessioned | 2025-07-08T11:27:55Z | |
| dc.date.available | 2025-07-08T11:27:55Z | |
| dc.date.issued | 2025 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | In tissue engineering, e-skin patches serve as wearable wound dressings for healing. In this study, electrospun nanofiber composites were developed by integrating PMMA, MXene, and chitosan (CS) to fabricate multifunctional e-skin scaffolds. The resulting PMMA–MXene–CS composite e-skin scaffolds exhibited a uniform fibrous morphology with average diameters of 600 ± 50 nm and high porosity (>85 %), providing an optimal microenvironment for tissue interfacing. Mechanical testing revealed that the PMMX:CS composite e-skin scaffold achieved a tensile strength of 13 MPa, a Young's modulus of 0.38 GPa, and elongation at break of 200 %, representing increases of 225 %, 36 %, and 43 %, respectively, over pure PMMA. Dielectric spectroscopy demonstrated a minimal loss tangent (<0.05) across 10–100 kHz and a built-in potential of 1.19 V, while electrochemical impedance measurements showed a charge-transfer resistance of 1.38 kΩ and a low leakage current, indicating excellent signal fidelity for sensing applications. Thermal conductivity tests under 10 GPa pressure yielded 28 W/m·K, ensuring rapid heat dissipation. Antimicrobial assays against Escherichia coli, Staphylococcus aureus, and Candida albicans confirmed inhibition rates of 95 %, 92 %, and 99 %, respectively, significantly outperforming control samples. Furthermore, antibacterial assays also demonstrated broad-spectrum efficacy, with inhibition zones up to 27.8 mm against Streptococcus pneumoniae and 26.4 mm against Listeria monocytogenes, and zones exceeding 25 mm for both Gram-negative and Gram-positive pathogens. Thus, obtained results revealed that the combination of PMMA, MXene and CS significantly enhanced inhibition against gram-negative bacteria compared to the control groups. Overall, PMMA-MXene-CS composite e-skin scaffold demonstrated promising mechanical, electrical, and antimicrobial properties, positioning them as strong candidates for next-generation flexible, durable, and multifunctional e-skin applications. | |
| dc.identifier.doi | 10.1016/j.ijbiomac.2025.145388 | |
| dc.identifier.issn | 01418130 | |
| dc.identifier.pmid | 40543788 | |
| dc.identifier.scopus | 105008653005 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.ijbiomac.2025.145388 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/13200 | |
| dc.identifier.volume | 319 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Akyüz Yılmaz, Bahar | |
| dc.language.iso | en | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | International Journal of Biological Macromolecules | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Antibacterial | |
| dc.subject | Chitosan | |
| dc.subject | Composite | |
| dc.subject | E-skin scaffold | |
| dc.subject | MXene | |
| dc.subject | PMMA | |
| dc.title | MXene-modified PMMA/chitosan composite e-skin scaffold: Bioelectronic and antibacterial assessment | |
| dc.type | Article |
