Evaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity

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dc.authorid0000-0003-0786-5077
dc.authorid0000-0003-2965-1811
dc.authorid0000-0001-9073-0864
dc.authorid0000-0001-7837-3948
dc.contributor.authorErdal, Hüseyin
dc.contributor.authorDemirtaş, Mehmet Semih
dc.contributor.authorKılıçbay, Fatih
dc.contributor.authorTunç, Gaffari
dc.date.accessioned2023-10-13T05:34:40Z
dc.date.available2023-10-13T05:34:40Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe aim of this study is to evaluate both dynamic thiol-disulfide homeostasis and oxidative stress (OS) levels in patients with retinopathy of prematurity (ROP). Methods: A total of 129 infants of <34 weeks gestational age were enrolled in the present study. The thiol-disulfide homeostasis was determined by using the new, cost-effective and fully automated colorimetric method. Total antioxidant status (TAS), Total oxidant status (TOS) and Oxidative stress index (OSI) levels were evaluated. Results: We found serum TAS levels were lower while serum TOS and OSI levels were significantly higher in patients with ROP compare to the without ROP group (p [removed].05). In addition, we also evaluated the native, total and disulfide levels in patients with ROP according to grades and no statistically significant results were found (p >.05). Low birth weight (p =.001), gestational age (p =.001) and 5-min Apgar score were significantly lower in the ROP group. Conclusion: This study revealed that dynamic thiol-disulfide homeostasis was changed in patients with ROP. Increased TOS and decreased TAS levels may be associated with functional reduction of the antioxidant system due to increased OS. This indicate that ROP patients are highly sensitive to OS. The dynamic thiol-disulfide homeostasis may conduce to the pathophysiological mechanism and disease follow-up in patients with ROP. The results of this study show that ROP patients are highly sensitive to oxidative stress.
dc.identifier.doi10.1080/02713683.2023.2185569
dc.identifier.issn0271-3683
dc.identifier.pmid36912268
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org10.1080/02713683.2023.2185569
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11156
dc.identifier.wosWOS:000949075100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOxidative Stress
dc.subjectRetinopathy of Prematurity
dc.subjectThiol-disulfide Homeostasis
dc.subjectNewborn
dc.subjectOxidants
dc.titleEvaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity
dc.typeArticle

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