The effects of in ovo administered of monosodium glutamate on the liver development in chicken embyos

Basit Öğe Kaydı
dc.contributor.authorBölükbaş, Ferhan
dc.contributor.authorYavuz, Orhan
dc.contributor.authorÖznurlu, Yasemin
dc.contributor.authorÖzaydın, Tuğba
dc.contributor.authorSur, Emrah
dc.date.accessioned2025-09-18T06:23:18Z
dc.date.available2025-09-18T06:23:18Z
dc.date.issued2025
dc.departmentVeteriner Fakültesi
dc.description.abstractMonosodium glutamate (MSG) is a widely used flavor enhancer/food additive around the world. The aim of this investigation was to analyze the effects of MSG administered in ovo on the development of the liver in chicken embryos using histological and immunohistochemical techniques. Four hundred ten fertilized hen’s eggs were categorized into five groups as follows: a control group, a distilled water group, and those containing MSG at three different concentrations, 0.12, 0.6, and 1.2 mg/g egg groups. The test solutions were injected into the yolk of eggs at just prior to incubation. The eggs from each group were opened randomly on the eighteenth and twenty first days of incubation to obtained 6 live embryos, and pieces of liver tissue were obtained. Hematoxylin and eosin, Crossmon's triple staining, and immunohistochemical staining of caspase-3 was performed. Histopathological alterations, including inflammatory cell infiltration and sinusoidal enlargement, were noted in the MSG-treated groups. Furthermore, MSG caused hydropic and vacuolar degenerations in the liver and to induced detachment in the alignment of the Remark cords, and an increased in caspase-3 positivity in the hepatocytes. Finally, it was found that in ovo administered of MSG affect on the embryonic development of the liver. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.
dc.identifier.doi10.1007/s10735-025-10529-w
dc.identifier.issn15672379
dc.identifier.issue4
dc.identifier.pmid40742617
dc.identifier.scopus2-s2.0-105012275118
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10735-025-10529-w
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14451
dc.identifier.volume56
dc.identifier.wosWOS:001542034300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorBölükbaş, Ferhan
dc.institutionauthorid0000-0002-9744-0242
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChicken Embryo
dc.subjectEmbryotoxicity
dc.subjectLiver
dc.subjectMonosodium Glutamate
dc.titleThe effects of in ovo administered of monosodium glutamate on the liver development in chicken embyos
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
bolukbas-ferhan-2025.pdf
Boyut:
3.42 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu