Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population: (Combined effect of two MIF gene promoter variations may play a role in Alzheimer’s disease)

Şahin, Kübra; Rüstemoğlu, Aydın

Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population: (Combined effect of two MIF gene promoter variations may play a role in Alzheimer’s disease)

dc.authorid	0000-0001-9870-0176
dc.authorid	0000-0002-1354-4598
dc.contributor.author	Şahin, Kübra
dc.contributor.author	Rüstemoğlu, Aydın
dc.date.accessioned	2023-10-09T05:57:16Z
dc.date.available	2023-10-09T05:57:16Z
dc.date.issued	2024
dc.department	Tıp Fakültesi
dc.description.abstract	In Alzheimer’s disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role in the pathogenesis of autoimmune/inflammatory diseases such as rheumatoid arthritis. The purpose of this study to investigate the association between Alzheimer disease and MIF gene promoter polymorphisms. The 205 patients with Alzheimer disease (AD) and 130 age-sex matched healthy individuals were investigated in terms of MIF -173 G/C and MIF ?794 CATT polymorphisms. The genotyping of MIF -173 G/C was determined using the RT-PCR method. MIF-794 CATT polymorphism was analyzed using PCR and DNA Sequencing. In terms of binary genotypes and haplotypes, the 5/5-GC (p = 0.004), 6/7-GG (p = 0.02) and, 6/6-GG (p = 0.026) binary genotypes, and 5-C (p = 0.003), 7-G (p = 0.026) and 6-G (p = 0.025) haplotypes were differed significantly between the patients and the controls. This is the first study investigating the relationship between AD and MIF in terms of different genotypes, haplotypes and, alleles. The fact that the binary genotype and allele distributions are significantly different between the patient and control group, suggests that this MIF variants may play a role in the pathogenesis of AD. © 2023
dc.identifier.doi	10.1080/15257770.2023.2253282
dc.identifier.issn	1525-7770
dc.identifier.pmid	37665108
dc.identifier.scopusquality	Q4
dc.identifier.uri	https:/dx.doi.org10.1080/15257770.2023.2253282
dc.identifier.uri	https://hdl.handle.net/20.500.12451/11092
dc.identifier.wos	WOS:001058163300001
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Taylor and Francis Ltd.
dc.relation.ispartof	Nucleosides, Nucleotides and Nucleic Acids
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	Alzheimer
dc.subject	Cytokine
dc.subject	Inflammation
dc.subject	MIF
dc.subject	Polymorphism
dc.title	Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population: (Combined effect of two MIF gene promoter variations may play a role in Alzheimer’s disease)
dc.type	Article