Investigation of the effects of morin on potassium bromate-induced brain damage in rats via different pathways with biochemical and histopathological methods

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dc.authorid0000-0002-5675-5096
dc.contributor.authorAygörmez, Serpil
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorGür, Cihan
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorMaraşlı, Şaban
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2025-07-09T07:53:57Z
dc.date.available2025-07-09T07:53:57Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractAim: Potassium bromate (KBrO3) is a colorless, odorless substance used as a food additive. It causes multiple organ damage and neurotoxicity. Morin is a flavonoid from the Moraceae family known to have anti-inflammatory, antioxidant, antiapoptotic, antiautophagic, and neuroprotective properties. Therefore, this study aimed to investigate the effects of Morin against KBrO3-induced brain damage. Methods: 62 mg/kg KBrO3 and 50–100 mg/kg Morin were administered to 35 male rats by oral gavage daily for 14 days. Various analyses were performed using molecular, biochemical, and histological methods. Results: The analyses results showed that KBrO3 application decreased antioxidant markers and raised lipid peroxidation in the brain tissue. The KBrO3 application triggered apoptosis, endoplasmic reticulum stress, and inflammation. Morin treatment increased enzymatic and nonenzymatic antioxidant levels and decreased lipid peroxidation. In addition, Morin alleviated KBrO3-induced apoptosis, endoplasmic reticulum stress, and inflammation in the brain tissue. The histopathological analysis revealed an increase in degenerative changes, as well as pyknotic changes and vacuolization in cells, in neurons in the KBrO3 group. Increased hyperemia and congestion were detected in the meninges and vessels in the cerebral cortex. Conclusion: KBrO3 application caused toxicity in the brain tissue and impaired tissue integrity, whereas Morin treatment alleviated KBrO3-induced toxicity.
dc.identifier.doi10.1016/j.fct.2025.115466
dc.identifier.issn02786915
dc.identifier.pmid40252904
dc.identifier.scopus105003928695
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2025.115466
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13215
dc.identifier.volume201
dc.identifier.wosWOS:001486338100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAkaras, Nurhan
dc.institutionauthorKandemir, Fatih Mehmet
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectBrain İnjury
dc.subjectEndoplasmic Reticulum Stress
dc.subjectMorin
dc.subjectOxidative Stress
dc.subjectPotassium Bromate
dc.titleInvestigation of the effects of morin on potassium bromate-induced brain damage in rats via different pathways with biochemical and histopathological methods
dc.typeArticle

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