Active nano/microbilayer hemostatic agents for diabetic rat bleeding model

Basit Öğe Kaydı
dc.authoridGumuskaya, Berrak -- 0000-0003-0599-8968
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorDemirbilek, Murat
dc.contributor.authorUlusoy, İbrahim
dc.contributor.authorGümşkaya, Berrak
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:14:53Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:14:53Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractPatients with diabetes mellitus have an increased cardiovascular risk due to the abnormality of hemostatic system components. Therefore, hemostasis is an important concept when considering that diabetics are under risk due to potential bleeding complications during surgical operation. The aim of our study was to examine the efficiency of a fabricated nano/microbilayer hemostatic dressing for bleeding control in diabetic patients. For this purpose, we prepared a nano/microbilayer hemostatic dressing that has a porous sublayer, including chitosan (CTS), bacterial cellulose (BC) as basement and active agents in coagulation cascade, such as vitamin K (Vit K), protamine sulfate (PS), and kaolin (Kao) as a filler and an upper layer consisting of silk fibroin (SF) or SF/phosphatidylcholine (PC) blend to achieve complete hemostasis in diabetic rats. Coagulative performances of the prepared hemostatic dressings were examined by the determination of bleeding time, blood loss, and mortality rate through diabetic rat femoral artery injury model. The percent of diabetic rat blood absorption was found to be 247 +/- 5% for gauze as opposed to 2214 +/- 56% for SF-coated PS/BC/CTS. Vit K-reinforced within 138 s and SF-coated BC/CTS hemostatic dressings within 144 s showed a rapid coagulation time. In vivo coagulation studies demonstrated that hemostatic agent-reinforced BC/CTS hemostatic dressing, especially PS/BC/CTS showed a significant hemostatic plug formation. This study suggests that the high positive charge and porosity give to these hemostatic agents reinforced hemostatic dressings the ability to rapidly swell and to promote the accumulation of red blood cells and platelets through electrostatic interactions. (C) 2016 Wiley Periodicals, Inc.
dc.description.sponsorshipHacettepe University Teaching Staff Training Program Office [014BIYP604003]
dc.description.sponsorshipContract grant sponsor: Hacettepe University Teaching Staff Training Program Office; contract grant number: 014BIYP604003
dc.identifier.doi10.1002/jbm.b.33696
dc.identifier.endpage1585en_US
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue6en_US
dc.identifier.pmid27126123
dc.identifier.scopusqualityQ1
dc.identifier.startpage1573en_US
dc.identifier.urihttps://doi.org/10.1002/jbm.b.33696
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4198
dc.identifier.volume105en_US
dc.identifier.wosWOS:000407055400026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBacterial Cellulose
dc.subjectChitosan
dc.subjectDiabetes Mellitus
dc.subjectHemostasis
dc.subjectNanofiber
dc.titleActive nano/microbilayer hemostatic agents for diabetic rat bleeding model
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
karahaliloglu-zeynep-2016 (1).pdf
Boyut:
1.17 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu