Determination of both the expression and serum levels of epidermal growth factor and transforming growth factor β1 genes in COVID-19

Basit Öğe Kaydı
dc.contributor.authorYıldız Gülhan, Pınar
dc.contributor.authorEröz, Recep
dc.contributor.authorÖztürk, Cihadiye Elif
dc.contributor.authorYekenkurul, Dilek
dc.contributor.authorAltınsoy, Hasan Baki
dc.contributor.authorGüleç Balbay, Ege
dc.contributor.authorErçelik, Merve
dc.contributor.authorDavran, Fatih
dc.contributor.authorYıldız, Şeyma
dc.date.accessioned2025-04-22T06:52:37Z
dc.date.available2025-04-22T06:52:37Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractWe aimed to evaluate the effects of both the expression and serum levels of Epidermal growth factor (EGF) and Transforming growth factor-β1 (TGF-β1) genes in patients with different degrees of cellular damage as mild, moderate, severe, and critical illness that can lead to fibrosis caused by SARS-CoV-2. Totally 45 individuals (male: 21(46.67%); female: 24(53.33%)) with COVID-19 infection were included in this study. Four groups were constituted as mild (n = 16)], moderate (n = 10), severe (n = 10), and critical (n = 9) according to the severity of the disease. Blood samples were drawn from the patients, and all of the hemograms, EGF and TGFβ1 gene expression, and serum levels were evaluated. The mean age of individuals was 57.311 ± 18.383 (min: 28, max: 94). Significant differences were found among the groups for PLT (χ2 = 9.955; p = 0.019), CRP (χ2 = 7.693; p = 0.053), Ferritin (χ2 = 22.196; p < 0.001), D-dimer (χ2 = 21.982; p = 0.000), LDH (χ2 = 21.807; p < 0.001) and all these parameters (exclude PLT in severe groups) was increased depending on the severity of the disease. Additionally, significant differences were detected for EGF (χ2 = 29.528; p < 0.001), TGFB1 (χ2 = 28.981; p < 0.001) expression (that increased depending on the disease severity), and EGF (χ2 = 7.84; p = 0.049), TGFB1 (χ2 = 17.451; p = 0.001) serum concentration levels (that decreased depending on the disease severity). This study found statistically significant differences for both EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt and EGF, TGFβ1 serum concentration values among all patient groups. As disease severity increased, EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt levels increased, while EGF and TGFβ1 serum concentration levels decreased. Perhaps this study will be useful in managing COVID-19 infection severity and pulmonary fibrosis cases secondary to COVID-19.
dc.identifier.doi10.1038/s41598-025-92304-1
dc.identifier.issue1
dc.identifier.pmid40118922
dc.identifier.scopus2-s2.0-105000490361
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-025-92304-1
dc.identifier.uri20452322
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13093
dc.identifier.volume15
dc.identifier.wos001449773000017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEröz, Recep
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCellular Damage
dc.subjectEpidermal Growth Factor
dc.subjectPulmonary Fibrosis
dc.subjectSARS-CoV-2
dc.subjectTransforming Growth Factor-β1
dc.subjectİnfection
dc.titleDetermination of both the expression and serum levels of epidermal growth factor and transforming growth factor β1 genes in COVID-19
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
yildiz gulhan-pinar-2025.pdf
Boyut:
2.47 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu