Increased triglyceride-glucose index predicts contrast-induced nephropathy in non-diabetic NSTEMI patients: A prospective study

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dc.contributor.authorAktaş, Halil
dc.contributor.authorİnci, Sinan
dc.contributor.authorGül, Murat
dc.contributor.authorGencer, Selman
dc.contributor.authorYıldırım, Oğuz
dc.date.accessioned2024-04-18T05:30:50Z
dc.date.available2024-04-18T05:30:50Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe triglyceride-glucose (TyG) index is a new reliable marker of insulin resistance (IR) and has recently been reported to be associated with renal dysfunction and contrast-induced nephropathy (CIN). Our aim in this study is to investigate the relationship between the TyG index and CIN in non-diabetic non-ST elevation acute myocardial infarction (NSTEMI) patients. The study included 272 non-diabetic patients who applied with NSTEMI and underwent coronary angiography (CAG). Patient data were divided into quartiles according to the TyG index: Q1: TyG?<?8.55; Q2: 8.55???TyG???8.87; Q3: 8.88???TyG???9.29; and Q4: TyG?>?9.29. Baseline characteristics, laboratory measurements, angiography data, and the incidence of CIN were compared between the groups. CIN was observed in 18 (6.6%) patients in the study. The incidence of CIN was lowest in the Q1 group and highest in the Q4 group (1 (1.5%) in Q1; 3 (4.4%) in Q2; 5 (7.4%) in Q3; 9 (13.2%) in Q4; p?=?0.040). TyG index was found to be an independent risk factor for the development of CIN in multivariate logistic regression analysis (odds ratio?=?6.58; confidence interval (CI)?=?2.12–20.40; p?=?0.001). TyG index value of 9.17 was identified as an effective cut-off point for the prediction of CIN (Area under the curve: 0.712, CI: 0.590–0.834, p?=?0.003), and it had a sensitivity of 61% and a specificity of 72%. The results of this study showed that a high TyG index increases the incidence of CIN after CAG in non-diabetic NSTEMI patients and is an independent risk factor for the development of CIN.
dc.identifier.doi10.1177/10815589231182317
dc.identifier.endpage844en_US
dc.identifier.issn1081-5589
dc.identifier.issue8en_US
dc.identifier.pmid37377036
dc.identifier.scopusqualityQ2
dc.identifier.startpage838en_US
dc.identifier.urihttps:/dx.doi.org10.1177/10815589231182317
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11636
dc.identifier.volume71en_US
dc.identifier.wosWOS:001098990000007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectContrast-induced Nephropathy
dc.subjectInsulin Resistance
dc.subjectNon-ST Elevation Acute Myocardial Infarction
dc.subjectTriglyceride-glucose Index
dc.titleIncreased triglyceride-glucose index predicts contrast-induced nephropathy in non-diabetic NSTEMI patients: A prospective study
dc.typeArticle

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