Thermoplastic Polyurethane-Oleic Acid (TPU-OLE) Membranes for Guided Bone Regeneration

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dc.authorid0000-0001-6711-9792
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorHazer, Baki
dc.date.accessioned2025-04-22T11:41:57Z
dc.date.available2025-04-22T11:41:57Z
dc.date.issued2025
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractGuided bone regeneration (GBR) is a regenerative surgical procedure in dentistry and orthopedics. The aim of this study is to fabricate a novel nano-textured, hydrophilic thermoplastic polyurethane (TPU)-based barrier membrane containing unsaturated fatty acid, oleic acid (OLE) to assist GBR. First, TPU copolymer containing OLE in different ratios was synthesized, and GBR membranes were fabricated by the solvent casting method, and then, the surface properties were improved by alkali treatment. Thus, a TPU-OLE structure was obtained with improved surface wettability, the ability to prevent bacterial adhesion, and the capability to promote cell adhesion. The contact angle reduced from 73.3° ± 1° to 30.7° ± 0.3° at TPU-OLE3, while at TPU it decreased from 121.2° ± 2.5° to 63.6° ± 0.8° after treatment with 3 M sodium hydroxide (NaOH) solution. Furthermore, plate counting assays showed that TPU-OLE membranes displayed excellent bacterial inhibition (against Escherichia coli and Staphylococcus aureus); the control group showed 6 × 107 CFU/mL of E. coli bacterial colonies, while on the plates interacting with TPU-OLE1, TPU-OLE2, and TPU-OLE3 membranes, colonies of 12 × 105, 12 × 105, and 24 × 105 CFU/mL were observed, respectively. The bacterial count on TPU-OLE1, TPU-OLE2, and TPU-OLE3 membranes decreased by 109, 164, and 12 × 105 CFU/mL at 24 h, while the control group and TPU membranes showed 1300 × 105 and 600 × 105 CFU/mL, respectively. The obtained results indicated that either alkali treatment or OLE-modified TPU produced a more hydrophilic and promotive surface for cell attachment. Therefore, we anticipate that alkali-treated TPU-OLE membranes have a great potential in GBR in future applications.
dc.identifier.doi10.1002/bip.70010
dc.identifier.issn00063525
dc.identifier.issue3
dc.identifier.pmid40099757
dc.identifier.scopus2-s2.0-105000683557
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1002/bip.70010
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13113
dc.identifier.volume16
dc.identifier.wos001446887100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorid0000-0001-6711-9792
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofBiopolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone Regeneration
dc.subjectMembrane
dc.subjectOleic Acid
dc.subjectThermoplastic Polyurethane
dc.subjectAlkali Treatment
dc.titleThermoplastic Polyurethane-Oleic Acid (TPU-OLE) Membranes for Guided Bone Regeneration
dc.typeArticle

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