PET-CT indications and contributions to diagnosis in the rheumatology clinic: a retrospective analysis
| dc.authorid | https://orcid.org/0000-0001-7007-1160 | |
| dc.contributor.author | Kahraman Denizhan, Tuğba | |
| dc.contributor.author | Kaplan, Hüseyin | |
| dc.contributor.author | Kızıltepe, Melih | |
| dc.contributor.author | Kökoğlu, Emel Oğuz | |
| dc.contributor.author | Cengiz, Celil Barlas | |
| dc.contributor.author | Abdulrezzak, Ümmühan | |
| dc.contributor.author | Şenel, Abdurrahman Soner | |
| dc.date.accessioned | 2025-09-18T12:34:20Z | |
| dc.date.available | 2025-09-18T12:34:20Z | |
| dc.date.issued | 2025 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Positron emission tomography-computed tomography (PET-CT) is a valuable imaging modality in both oncology and autoimmune or inflammatory diseases. This study evaluates the indications for PET-CT in rheumatology patients, compares PET-CT findings with other imaging modalities, and assesses its contribution to definitive diagnosis. Methods: Between January 2022 and December 2023, 63 patients (38 women, 25 men) who underwent PET-CT at Erciyes University Rheumatology Clinic were retrospectively analyzed. Clinical, laboratory, and imaging findings—including prior CT, magnetic resonance imaging (MRI), and angiographic evaluations—were reviewed. PET-CT findings were classified based on metabolic uptake patterns indicating malignancy, vasculitis, inflammatory involvement, lymphadenopathy, and IgG4-related diseases. PET-CT results were statistically compared with final diagnoses. Results: The most common indications for PET-CT were suspected vasculitis (42.9%), fever/inflammation of unknown origin (30.2%), and suspected malignancy (27.0%). PET-CT detected inflammation in 65.1% of cases, lymphadenopathy in 52.4%, nodules in 41.3%, malignancy in 31.7%, and vasculitis in 20.6%. Vasculitis findings were significantly higher in patients with pre-existing rheumatic disease (p = 0.012), while malignancy-related findings were more frequent in those without (p = 0.025). Anti-SSA and anti-Scl70 positivity were significantly associated with malignancy (p = 0.003 and p = 0.030, respectively). PET-CT effectively detected malignancy (p < 0.001) but showed limited diagnostic accuracy for vasculitis (47.6%). Conclusion: PET-CT complements conventional imaging in evaluating vasculitis, inflammation, and malignancy in rheumatic diseases. However, it is insufficient for diagnosing vasculitis alone, necessitating a comprehensive clinical and laboratory approach. While PET-CT is highly effective in malignancy detection, autoantibody presence should be carefully considered in suspected cases. | |
| dc.identifier.doi | 10.1007/s10067-025-07635-1 | |
| dc.identifier.issn | 07703198 | |
| dc.identifier.scopus | 2-s2.0-105013468652 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://doi.org/10.1007/s10067-025-07635-1 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/14481 | |
| dc.identifier.wos | WOS:001551618100001 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | Web of Science | |
| dc.institutionauthor | Kaplan, Hüseyin | |
| dc.language.iso | en | |
| dc.publisher | Springer Science and Business Media Deutschland GmbH | |
| dc.relation.ispartof | Clinical Rheumatology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Autoimmune Diseases · | |
| dc.subject | Inflammation | |
| dc.subject | Malignancy | |
| dc.subject | PET-CT | |
| dc.subject | Rheumatology | |
| dc.subject | Vasculitis | |
| dc.title | PET-CT indications and contributions to diagnosis in the rheumatology clinic: a retrospective analysis | |
| dc.type | Article |
