Antitumor activities on HL-60 human leukemia cell line, molecular docking, and quantum-chemical calculations of some sulfonamide-benzoxazoles

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dc.contributor.authorÖksüzoğlu, Emine
dc.contributor.authorErtan Bolelli, Tuğba
dc.contributor.authorCan, Hatice
dc.contributor.authorTarhan, Mehtap
dc.contributor.authorÖzturk, Kamile
dc.contributor.authorYıldız, İlkay
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:18:06Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:18:06Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractWe previously synthesized some novel benzoxazole derivatives-containing sulfonamide. In this study, the compounds were investigated for their antitumor activities against the HL-60 human leukemia cells, using the MTT assay. Moreover, quantum chemical calculations using the DFT methods were applied for understanding the difference in antitumor activity. Additionally, molecular docking into active site of the DNA Topo II enzyme was performed on 3QX3. PDB file in order to find out possible mechanism of antitumor effect. According to all obtained results showed that compounds 1b, 1c, and 1d could be potential drug candidates as new antitumor agents, and are promising for cancer therapy.
dc.description.sponsorshipScientific Research Project of Aksaray University [2014-022]; Scientific Research Project of Ankara University [16H0237002]
dc.description.sponsorshipThis study was supported by the Scientific Research Project of Aksaray University [grant number: 2014-022] and the Scientific Research Project of Ankara University [grant number: 16H0237002].
dc.identifier.doi10.1080/21691401.2016.1241796
dc.identifier.endpage1396en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue7en_US
dc.identifier.pmid27829297
dc.identifier.scopusqualityQ1
dc.identifier.startpage1388en_US
dc.identifier.urihttps://doi.org/10.1080/21691401.2016.1241796
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4836
dc.identifier.volume45en_US
dc.identifier.wosWOS:000413975300017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArtificial Cells Nanomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntitumor Activity
dc.subjectBenzoxazole
dc.subjectSulfonamide
dc.subjectHL-60 Human Leukemia Cell Line
dc.subjectMolecular Docking
dc.subjectQuantum Chemical Calculations
dc.subjectTopoisomerase II
dc.titleAntitumor activities on HL-60 human leukemia cell line, molecular docking, and quantum-chemical calculations of some sulfonamide-benzoxazoles
dc.typeArticle

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