Preparation of cryogel columns for depletion of hemoglobin from human blood

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dc.contributor.authorDerazshamshir, Ali
dc.contributor.authorBaydemir, Gözde
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorBereli, Nilay
dc.contributor.authorDenizli, Adil
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:51Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:51Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractIn this study, we aimed to prepare the metal chelate affinity cryogels for the hemoglobin (Hb) depletion. Poly(2-hydroxyethyl methacrylate) (PHEMA) cryogels were selected as base matrix because of their blood compatibility, osmotic, chemical, and mechanical stability. Cryogels are also useful when working with the viscous samples such as blood, because of their interconnected macroporous structure. Iminodiacetic acid (IDA), the chelating agent, was covalently coupled with PHEMA cryogels after activation with the epichlorohydrin and then the Ni(II) ions were chelated to the IDA-bound cryogels. The depletion of the Hb from hemolysate was shown by SDS-PAGE.
dc.identifier.doi10.3109/21691401.2015.1129623
dc.identifier.endpage799en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue3en_US
dc.identifier.pmid26772759
dc.identifier.scopusqualityQ1
dc.identifier.startpage792en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2015.1129623
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6093
dc.identifier.volume44en_US
dc.identifier.wosWOS:000376136500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofArtificial Cells, Nanomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHemoglobin Depletion
dc.subjectIDA
dc.subjectMetal Chelate Sffinity Sorbents
dc.subjectPHEMA Cryogel
dc.titlePreparation of cryogel columns for depletion of hemoglobin from human blood
dc.typeArticle

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