Effects of oral sotretinoin on normal and wounded nasal mucosa: An experimental study

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dc.contributor.authorCengiz, Abdurrahman Buğra
dc.contributor.authorÖzyılmaz, Cemal
dc.contributor.authorTabaru, Alper
dc.contributor.authorKayabaşı, Serkan
dc.contributor.authorEge, Sertuğ Sinan
dc.contributor.authorRüzgar, Sedat
dc.contributor.authorEmre, Funda
dc.contributor.authorOktay, Mehmet Faruk
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:16:48Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:16:48Z
dc.date.issued2018
dc.departmentTıp Fakültesi
dc.description.abstractBackgroundWe aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model.MethodsCircular mucosal defect with a 7mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1wounded-drug given side, 2unwounded and drug-given side, 3wounded-control and 4unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4weeks.ResultsAt both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 mu (26.24), and in the control group, mean mucosal thickness was 238.33 mu (+/- 39.7) at the wounded side. (p<0.001). The difference between the groups in thickness of normal septal mucosa was also statistically significant (p=0.016) [190 mu (+/- 14.6) and 256.66 mu (+/- 44.66)]. The average cilia level was observed 1.16 in the wounded study group, while the average level was 2.33 in the wounded control group (p=0.012). Average score measurements of the regenerated mucosa suggested that isotretinoin-given wounded animals have reduced goblet cell recovery, compared to the control both on the regenerated and unwounded mucosas (p=0.007, p=0.002, respectively). Inflammation was significantly higher in the wounded isotretinoin group (p=0.018).Conclusion Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes.
dc.identifier.doi10.1007/s00405-018-5190-2
dc.identifier.endpage3031en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue12en_US
dc.identifier.pmid30382397
dc.identifier.scopusqualityQ1
dc.identifier.startpage3025en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-018-5190-2
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4656
dc.identifier.volume275en_US
dc.identifier.wosWOS:000450099400016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOral Isotretinoin
dc.subjectNasal Mucosa
dc.subjectHealing
dc.titleEffects of oral sotretinoin on normal and wounded nasal mucosa: An experimental study
dc.typeArticle

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