Proanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/reperfusion injury in rats

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dc.contributor.authorKazak, Filiz
dc.contributor.authorAkçakavak, Gökhan
dc.contributor.authorAlakuş, İbrahim
dc.contributor.authorAlakuş, Halil
dc.contributor.authorKırgız, Ömer
dc.contributor.authorKarataş, Özhan
dc.contributor.authorDeveci, Mehmet Zeki Yılmaz
dc.contributor.authorCoşkun, Pınar
dc.date.accessioned2024-07-24T05:37:12Z
dc.date.available2024-07-24T05:37:12Z
dc.date.issued2024
dc.departmentVeteriner Fakültesi
dc.description.abstractTesticular torsion is an urological emergency and can lead to ischemia damage and testicular loss if not diagnosed in time. Proanthocyanidin is reported to have anti-inflammatory and antioxidant properties. The current study aimed to examine the possible effects of proanthocyanidin (P) on the testis in torsion/detorsion (T/D)-induced testicular ischemia/reperfusion (I/R) injury in rats. Forty rats were divided into four groups (n=10 for each): sham-operated (sham), I/R, I/R + P100 (100?mg/kg, 30?min before torsion), and I/R + P200 (200?mg/kg, 30?min before torsion). Testicular T/D was performed on the left testicle by 3?hours of torsion at 720° clockwise, followed by 3?hours of detorsion. In the I/R group, an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH), vitamin C (Vit C), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD) values were determined compared to the sham group (p<0.001). Moreover, an increase in the expression of cleaved caspase-3 and Bcl2-associated X protein (Bax), a decrease in the expression of B-cell lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were detected in the I/R group (p<0.001). Histopathologically, it was determined that the Johnsen and Cosentino scores of the testicles were irregular in the I/R group (p<0.001). Proanthocyanidin treatment caused a decrease in MDA, cleaved caspase-3 and Bax levels and an increase in GSH, Vit C, GPx, G6PD, Bcl-2 and PCNA values. Additionally, Johnsen and Cosentino rearranged the scores. The present findings revealed the protective and curative effects of proanthocyanidin in organ damage due to testicular torsion/detorsion-induced ischemia/reperfusion with their antioxidative and antiapoptotic properties.
dc.identifier.issue-en_US
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12208
dc.identifier.volume89en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTissue and Cell
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOxidative Stress
dc.subjectBax
dc.subjectBcl-2
dc.subjectCleaved Caspase-3
dc.subjectProanthocyanidin
dc.subjectTorsion/detorsion
dc.titleProanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/reperfusion injury in rats
dc.typeArticle

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