C-reactive protein-to-albumin ratio and systemic immune-inflammatory index as potential markers in distinguishing acute cerebellar infarction from benign paroxysmal positional vertigo

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dc.contributor.authorŞahin, Oruç
dc.contributor.authorGüneş, Muzaffer
dc.contributor.authorDönmez, Recep
dc.date.accessioned2025-07-18T13:33:15Z
dc.date.available2025-07-18T13:33:15Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractTo investigate the potential utility of the C-reactive protein-to-albumin ratio (CAR) and the systemic immune-inflammatory index (SII) as a biomarker in distinguishing between BPPV and acute cerebellar infarction (ACI) due to posterior inferior cerebellar artery (PICA) involvement. METHODS: The data of 2545 patients registered in our hospital database between 2017 and 2024 with a diagnosis of vertigo were retrospectively analyzed and 102 patients with benign paroxysmal positional vertigo (BPPV) and 100 patients with ACI were included in the study. Mann-Whitney U test, Chi-square test, or Fisher's exact test were used to compare variables between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of the data. RESULTS: The CAR and SII values were significantly higher in the ACI group compared to the BPPV group (p<0.001, p<0.001, respectively). The areas under the ROC curve (AUC) were as follows: CAR=0.768 (95% CI, 0.705-0.832), white blood cell count (WBC)=0.735 (95% CI, 0.667-0.802), monocytes=0.622 (95% CI, 0.544-0.699), red cell distribution width-standard deviation (RDW-SD)=0.600 (95% CI, 0.522-0.678), SII=0.674 (95% CI, 0.599-0.748), and neutrophil-to-lymphocyte ratio (NLR)=0.687 (95% CI, 0.613-0.761). CONCLUSION: CAR and SII could be useful biomarkers to differentiate between ACI and BPPV in vertigo patients, but further validation is needed in larger studies.
dc.identifier.doi10.17712/nsj.2025.1.20240084
dc.identifier.endpage35
dc.identifier.issnhttps://dx.doi.org/13196138
dc.identifier.issue1
dc.identifier.pmid39800414
dc.identifier.scopus85215352213
dc.identifier.startpage30
dc.identifier.uri10.17712/nsj.2025.1.20240084
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13394
dc.identifier.volume30
dc.identifier.wosWOS:001439902800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahin, Oruç
dc.institutionauthorGüneş, Muzaffer
dc.institutionauthorDönmez, Recep
dc.language.isoen
dc.publisherRiyadh Armed Forces Hospital
dc.relation.ispartofNeurosciences (Riyadh, Saudi Arabia)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdult
dc.subjectAged
dc.subjectBenign Paroxysmal Positional Vertigo
dc.subjectBiomarkers
dc.subjectBrain Infarction
dc.subjectC-Reactive Protein
dc.subjectCerebellar Diseases
dc.subjectDiagnosis
dc.subjectDifferential
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.titleC-reactive protein-to-albumin ratio and systemic immune-inflammatory index as potential markers in distinguishing acute cerebellar infarction from benign paroxysmal positional vertigo
dc.typeArticle

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