Microsphere-embedded cryogel for selective and efficient depletion of immunoglobulin G from human serum

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dc.contributor.authorBaydemir, Gözde
dc.contributor.authorOdabaşı, Mehmet
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:49Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:49Z
dc.date.issued2013
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractIn this study a novel composite cryogel column was synthesized for affinity depletion of immunoglobulin G (IgG) from human serum. The microsphere-embedding technique combines the large surface area of microspheres with excellent properties of cryogels. The poly(hydroxyethyl methacrylate-N-methacryloyl-L-histidine methyl ester) microsphere (2 m m size)embedded composite cryogel (MECC) column was synthesized and characterized by various methods. The specific surface area of the composite cryogel was found as 92 m(2)/g by using BET measurement. Maximum HIgG adsorption on MECC column was found as 50.5 mg/g. MECC column can be reused many times with no apparent decrease in HIgG adsorption capacity.
dc.identifier.doi10.3109/21691401.2012.743904
dc.identifier.endpage326en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue5en_US
dc.identifier.pmid23305035
dc.identifier.scopusqualityQ1
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2012.743904
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5936
dc.identifier.volume41en_US
dc.identifier.wosWOS:000325095600006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofArtificial Cells, Nanomedicine, and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectComposite Cryogel
dc.subjectIgG Affinity Depletion
dc.subjectMicrosphere Embedding
dc.subjectProtein Adsorption
dc.titleMicrosphere-embedded cryogel for selective and efficient depletion of immunoglobulin G from human serum
dc.typeArticle

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