Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue

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dc.authorid0000-0003-4450-6540
dc.authorid0000-0002-8222-5515
dc.authorid0000-0001-6775-7858
dc.contributor.authorTuncer, Sibel Çiğdem
dc.contributor.authorAkarsu, Serkan Ali
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorGür, Cihan
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2023-10-10T10:45:51Z
dc.date.available2023-10-10T10:45:51Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractIn this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was administered at a dose of 30 mg/kg/bw for 7 days to induce testicular toxicity in rats. Oral doses of 5 and 10 mg/kg/bw SNP were administered to rats for 7 days after PbAc administration. According to our findings, while PbAc administration increased MDA content in rats, it decreased GPx, SOD, CAT activity and GSH content. NF-kB, IL-1?, TNF-?, and COX-2, which are among the inflammation parameters that increased due to PbAc, decreased with the administration of SNP. Nrf2, HO-1, and NQO1 mRNA transcript levels decreased with PbAc, but SNP treatments increased these mRNA levels in a dose-dependent manner. RAGE and NLRP3 gene expression were upregulated in PbAc treated rats. MAPK14, MAPK15, and JNK relative mRNA levels decreased with SNP treatment in PbAc treated rats. While the levels of apoptosis markers Bax, Caspase-3, and Apaf-1 increased in rats treated with PbAc, the level of Bcl-2 decreased, but SNP inhibited this apoptosis markers. PbAc caused histopathological deterioration in testis tissue and negatively affected spermatogenesis. When the sperm quality was examined, the decrease in sperm motility and spermatozoon density caused by PbAc, and the increase in the ratio of dead and abnormal spermatozoa were inhibited by SNP. As a result, while PbAc increased apoptosis and inflammation by inducing oxidative stress in testicles, SNP treatment inhibited these changes and increased sperm quality.
dc.identifier.doi10.1002/tox.23900
dc.identifier.issn1520-4081
dc.identifier.pmid37471654
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org10.1002/tox.23900
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11116
dc.identifier.wosWOS:001032433600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofEnvironmental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectInflammation
dc.subjectLead Acetate
dc.subjectOxidative Stress
dc.subjectSinapic Acid
dc.titleEffects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue
dc.typeArticle

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