Investigation of the effects of monosodium glutamate on the embryonic development of the eye in chickens

dc.authorid0000-0002-9744-0242
dc.contributor.advisorÖznurlu, Yasemin
dc.contributor.authorBölükbaş, Ferhan
dc.date.accessioned2023-03-13T05:54:47Z
dc.date.available2023-03-13T05:54:47Z
dc.date.issued2023
dc.departmentVeteriner Fakültesi
dc.description.abstractMSG is the most ubiquitous food additive in the food industry. The aim of this report was to investigate the effects of in ovo MSG administration on embryonic chicken eye development using histological and histometric methods. A total of 410 fertilized eggs obtained from Babcock Brown laying hens (Gallus gallus domesticus) were used and divided into 5 groups: I (untreated control), II (vehicle control), III (0.12 mg/g egg MSG), IV (0.6 mg/g egg MSG), and V (1.2 mg/g egg MSG), and injections were performed via the egg yolk. At incubation day 15, 18, and 21, 6 embryos from each group were sacrificed by decapitation and pieces of eye tissue were obtained. In all MSG groups, it was determined that both corneal epithelium thickness and total corneal thickness decreased at incubation time points 15, 18, and 21 days compared with the controls (p < 0.05). The total retinal thickness, thickness of the outer nuclear layer (ONL), inner nuclear layer (INL), ganglion cell layer (GL), and nerve fibre layers (NFL), as well as the number of ganglion cells decreased significantly at incubation days 15, 18, and 21 (p < 0.05), and degenerative changes such as vacuolar degeneration and retinal pigment epithelial detachment were also observed. In conclusion, MSG in ovo administration can affect the cornea and distinct layers of retinal cells.
dc.identifier.doi10.3390/vetsci10020099
dc.identifier.issn2306-7381
dc.identifier.issue2en_US
dc.identifier.pmid36851403
dc.identifier.scopusqualityQ2
dc.identifier.urihttps:/dx.doi.org/10.3390/vetsci10020099
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10330
dc.identifier.volume10en_US
dc.identifier.wosWOS:000942012200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofVeterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMonosodium Glutamate
dc.subjectRetina
dc.subjectCornea
dc.subjectEye
dc.subjectGanglion Cells
dc.subjectChicken Embryos
dc.titleInvestigation of the effects of monosodium glutamate on the embryonic development of the eye in chickens
dc.typeArticle

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