GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations

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dc.authoridPolimanti, Renato -- 0000-0003-0745-6046
dc.contributor.authorKaraca, Şefayet
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorCesuroğlu, Tomris
dc.contributor.authorErge, Sema
dc.contributor.authorPolimanti, Renato
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:48Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:48Z
dc.date.issued2015
dc.departmentSağlık Bilimleri Fakültesi
dc.description.abstractObjective: Glutathione S-transferase (GST) variants have been widely investigated to better understand their role in several pathologic conditions. To our knowledge, no data about these genetic polymorphisms within the Turkish population are currently available. The aim of this study was to analyze GSTM1 positive/null, GSTT1 positive/null, GSTP1*I105V (rs1695), and GSTP1*A114V (rs1138272) variants in the general Turkish population, to provide information about its genetic diversity, and predisposition to GST-related diseases. Methods: Genotyping was performed in 500 Turkish individuals using the Sequenom MassARRAY platform. A comparative analysis was executed using the data from the HapMap and Human Genome Diversity Projects (HGDP). Sequence variation was deeply explored using the Phase 1 data of the 1,000 Genomes Project. ResultsThe variability of GSTM1, GSTT1, and GSTP1 polymorphisms in the Turkish population was similar to that observed in Central Asian, European, and Middle Eastern populations. The high linkage disequilibrium between GSTP1*I105V and GSTP1*A114V in these populations may have a confounding effect on GSTP1 genetic association studies. In analyzing GSTM1, GSTT1, and GSTP1 sequence variation, we observed other common functional variants that may be candidates for associated studies of diseases related to GST genes (e.g., cancer, cardiovascular disease, and allergy). Conclusions: This study provides novel data about GSTM1 positive/null, GSTT1 positive/null, GSTP1*I105V, and GSTP1*A114V variants in the Turkish population, and other functional variants that may affect GSTM1, GSTT1, and GSTP1 functions among worldwide populations. This information can assist in the design of future genetic association studies investigating oxidative stress-related diseases. Am. J. Hum. Biol. 27:310-316, 2015. (c) 2014 Wiley Periodicals, Inc.
dc.description.sponsorshipGENAR Institute for Public Health and Genomics Research
dc.description.sponsorshipContract grant sponsors: GENAR Institute for Public Health and Genomics Research.
dc.identifier.doi10.1002/ajhb.22671
dc.identifier.endpage316en_US
dc.identifier.issn1042-0533
dc.identifier.issn1520-6300
dc.identifier.issue3en_US
dc.identifier.pmid25515186
dc.identifier.scopusqualityQ1
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1002/ajhb.22671
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5712
dc.identifier.volume27en_US
dc.identifier.wosWOS:000353299400003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal of Human Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.titleGSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations
dc.typeArticle

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