Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis

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dc.authorid0000-0003-0999-2774
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorÖzgen, Merih
dc.contributor.authorTurgut Coşan, Didem
dc.contributor.authorKurt, Hülyam
dc.contributor.authorDoğaner, Fulya
dc.contributor.authorArmag?n, Onur
dc.contributor.authorDe?irmenci, İrfan
dc.contributor.authorMutlu, Fezan Şahin
dc.date.accessioned2020-09-21T06:18:29Z
dc.date.available2020-09-21T06:18:29Z
dc.date.issued2020
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.descriptionDoğaner, Fulya ( Aksaray, Yazar )
dc.description.abstractThe present study was aimed to investigate the relationship between NOD1/CARD4 and NOD2/CARD15 gene polymorphisms and osteoporosis in the Turkish population. The first time we thought that the functional polymorphisms in NOD1/CARD4 and NOD2/CARD15 genes might have triggered the development of osteoporosis. The objective of our study was to determine the relationship between NOD1/CARD4 and NOD2/CARD15 SNPs and osteoporosis. The NOD1/CARD4 (rs5743336) and NOD2/CARD15 (rs2066847) SNPs were analyzed by PCR restriction fragment length polymorphism (PCR-RFLP) in 94 healthy controls and 164 subjects with osteoporosis. PCR products were digested with restriction enzymes AvaI for NOD1/CARD4 and ApaI for NOD2/CARD15. We found that NOD1/CARD4 genotype distribution of AA, GA and GG were 15, 44 and 41% for patients and 17, 46 and 37% for controls, respectively. NOD2/CARD15 mutation was found only in three patients (1.8%) as heterozygote. The results did not show any statistical difference between NOD1/CARD4 and NOD2/CARD15 genotype distribution of patients and healthy groups (?2 = 1.740, P=0.187; ?2 = 1.311, P=0.519). However, the most frequent AG genotype (46%) of NOD1/CARD4 was observed in healthy controls, GG genotype (44%) of NOD1/CARD4 was observed as the most frequent in osteoporotic patients. NOD2/CARD15 WT/WT genotype, the most frequent genotype, was observed in both groups. Statistical analysis revealed that NOD1/CARD4 and NOD2/CARD15 polymorphisms are not associated with osteoporosis. However, a definite judgement is difficult to be made due to restricted number of patients and small size of control group. Further research is sorely warranted in this direction.
dc.identifier.doi10.1042/BSR20192313
dc.identifier.endpage-en_US
dc.identifier.issn0144-8463
dc.identifier.issue7en_US
dc.identifier.otherPubMed ID: 32578848
dc.identifier.otherArticle number BSR20192313
dc.identifier.pmid32578848
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1042/BSR20192313
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7674
dc.identifier.volume40en_US
dc.identifier.wosWOS:000561027400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPortland Press Ltd
dc.relation.ispartofBioscience Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGenetic Variation
dc.subjectNOD1/CARD4
dc.subjectNOD2/CARD15
dc.titleGenetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis
dc.typeArticle

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