In vitro tyrosinase inhibitory and antioxidant potential of Consolida orientalis, Onosma isauricum and Spartium junceum from Turkey

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dc.authoridZengin, Gokhan -- 0000-0001-6548-7823
dc.contributor.authorZengin, G.
dc.contributor.authorMahomoodally, M. F.
dc.contributor.authorPicot-Allain, C. M. N.
dc.contributor.authorÇakmak, Y. S.
dc.contributor.authorUysal, S.
dc.contributor.authorAktümsek, A.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:29:52Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:29:52Z
dc.date.issued2019
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractTraditionally used botanical remedies have attracted much interest as pharmacological targets in the management and/or treatment of several diseases. Recently, they have been probed as tyrosinase inhibitors for the management of epidermal hyperpigmentation. This study aims to investigate into the antioxidant and tyrosinase inhibitory potential of methanol, ethyl acetate, and water extracts of three medicinal plants (Consolida orientalis (J. Gay) Schrodinger, Onosma isauricumBoiss. & Heldr. and Spartium junceumL.), fromTurkey. Methanolic extract of O. isauricum and S. junceum showed the highest phenolic (63.08 mgGAE/g extract) and flavonoid contents (45.55 mgRE/g extract). Additionally, O. isauricum methanolic extract exhibited the most powerful antioxidant capacity followed by methanolic extract of S. junceum (86.02 and 62.81 mgAAE/g extract, respectively). S. junceum extracts yielded the higher kojic acid equivalent values (21.42-23.04 mgKAE/g extract), confirming that these extracts were the most potent inhibitors of tyrosinase. S. junceum showed promising activity that warrant further studies and could be considered as a potent candidate for the development of phytoremedies for the management of epidermal hyperpigmentation. To the best of our knowledge, this study can be considered as the first report of on the antioxidant and tyrosinase inhibitory action of C. orientalis, O. isauricum, and S. junceum from Turkey. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.sajb.2018.01.010
dc.identifier.endpage123en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopusqualityQ1
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2018.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6216
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant
dc.subjectTyrosinase
dc.subjectPhenolic
dc.subjectFlavonoid
dc.subjectHyperpigmentation
dc.subjectEnzyme Inhibitors
dc.subjectBotanical Remedies
dc.titleIn vitro tyrosinase inhibitory and antioxidant potential of Consolida orientalis, Onosma isauricum and Spartium junceum from Turkey
dc.typeArticle

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