In vitro tyrosinase inhibitory and antioxidant potential of Consolida orientalis, Onosma isauricum and Spartium junceum from Turkey
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Traditionally used botanical remedies have attracted much interest as pharmacological targets in the management and/or treatment of several diseases. Recently, they have been probed as tyrosinase inhibitors for the management of epidermal hyperpigmentation. This study aims to investigate into the antioxidant and tyrosinase inhibitory potential of methanol, ethyl acetate, and water extracts of three medicinal plants (Consolida orientalis (J. Gay) Schrodinger, Onosma isauricumBoiss. & Heldr. and Spartium junceumL.), fromTurkey. Methanolic extract of O. isauricum and S. junceum showed the highest phenolic (63.08 mgGAE/g extract) and flavonoid contents (45.55 mgRE/g extract). Additionally, O. isauricum methanolic extract exhibited the most powerful antioxidant capacity followed by methanolic extract of S. junceum (86.02 and 62.81 mgAAE/g extract, respectively). S. junceum extracts yielded the higher kojic acid equivalent values (21.42-23.04 mgKAE/g extract), confirming that these extracts were the most potent inhibitors of tyrosinase. S. junceum showed promising activity that warrant further studies and could be considered as a potent candidate for the development of phytoremedies for the management of epidermal hyperpigmentation. To the best of our knowledge, this study can be considered as the first report of on the antioxidant and tyrosinase inhibitory action of C. orientalis, O. isauricum, and S. junceum from Turkey. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Antioxidant, Tyrosinase, Phenolic, Flavonoid, Hyperpigmentation, Enzyme Inhibitors, Botanical Remedies
Kaynak
South African Journal of Botany
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
120
