N-methyl-D-aspartate receptor antagonists may ameliorate spinal cord injury by inhibiting oxidative stress: An experimental study in rats
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurosurgical Society / Türk Nöroşirürji Derneği
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM: To investigate the neuroprotective effect of a N-methyl-D-aspartate (NM DA) receptor antagonist (amantadine) in an experimental spinal cord injury (SCI) model. MATERIAL and METHODS: Thirty male Sprague-Dawley rats were divided into three groups: control (I), SCI (II), and SCI + amantadine (III). SCI was created using clip compression technique. At the end of day 7, blood samples were obtained from the rats and analyzed using various biochemical markers. Histological examination was also performed. MDA, GSH, and MPO assays were done. VEGF, TNF-alpha, and Baxexpressions were also analyzed. RESULTS: The group III had several inflammatory cells in the gray and white matter, with mildly degenerated multipolar and bipolar cells. Some bipolar and multipolar neurons showed TNF-alpha expression; however, TNF-alpha was found to be weak in small groups of inflammatory cells around the blood vessels in the substantia grisea and alba. Positive Bax expression was observed in the substantia grisea layer, particularly in the membrane of some bipolar neurons and glial cells; however, negative Bax expression was observed in neuron and glial cells and showed positive VEGF expression in the vascular endothelium in the group III. CONCLUSION: NMDA receptor antagonists, especially amantadine, may ameliorate SCI by inducing angiogenesis, affecting inflammation and apoptosis. It inhibits oxidative stress and the signaling pathways following SCI in rats.
Açıklama
Karaca, Onur ( Aksaray, Yazar )
Anahtar Kelimeler
Amantadine, Oxidative Stress, Spinal Cord Injury, Rat, VEGF
Kaynak
Turkish Neurosurgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
30
Sayı
1
