45S5 bioactive glass-Ointment positively effects on wound healing in rats by regulating TNF?, Il-10, VEGF, and TGF?

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dc.authorid0000-0002-0222-1363
dc.authorid0000-0003-3896-9944
dc.authorid0000-0001-5753-8985
dc.authorid0000-0001-9178-6261
dc.authorid0000-0001-5949-4752
dc.authorid0000-0002-4864-0598
dc.authorid0000-0002-9495-9321
dc.contributor.authorKırgız, Ömer
dc.contributor.authorAltuğ, Muhammed Enes
dc.contributor.authorÖzkan, Hüseyin
dc.contributor.authorHan, Mehmet Cengiz
dc.contributor.authorAkçakavak, Gökhan
dc.contributor.authorÖzarslan, Ali Can
dc.contributor.authorYücel, Sevil
dc.date.accessioned2024-09-23T11:41:49Z
dc.date.available2024-09-23T11:41:49Z
dc.date.issued2024
dc.departmentVeteriner Fakültesi
dc.description.abstractThis study aimed to investigate the effects of 45S5 bioactive glass-ointment (BG) on cutaneous wound healing in rats at the molecular, biochemical, and histopathological levels.Materials and MethodsThirty-two rats were divided into four groups (n = 8): Control, Sham, BG, and DEX (Dexpanthenol). While no wound treatment was applied to the CONTROL, a wound model was created in the Sham, and no treatment was applied. A wound model was created for other groups, and BG and DEX were applied locally for 21 days. During the 21-day experiment period, feed and water consumption and weight changes were observed. Wound areas were calculated on days 0, 3, 7, 4, and 21. Following treatment, the rats were euthanized and tissues from the wound area and blood samples were collected. While the expression levels of tumor necrosis factor-alpha (TNF alpha), Interleukin 6 (IL6), Interleukin 10 (IL10), transforming growth factor-beta (TGF beta), and vascular endothelial growth factor (VEGF) genes were determined by qPCR, the levels of TNF alpha, IL6, and IL10 proteins were measured by ELISA.ResultsIt was observed that the BG group showed anti-inflammatory activity by suppressing TNF alpha levels and stimulating IL-10. In addition, it was determined that BG increased fibroblast activity and vascularization.ConclusionCurrent findings showed that topical application of BG has anti-inflammatory effects, while also accelerating healing by increasing vascularity and making positive contributions to tissue healing.
dc.identifier.doi10.1002/jcla.25094
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org/10.1002/jcla.25094
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12447
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioactive Glasses
dc.subjectELISA
dc.subjectGene Expression
dc.subjectHistopathology
dc.subjectWound Healing
dc.title45S5 bioactive glass-Ointment positively effects on wound healing in rats by regulating TNF?, Il-10, VEGF, and TGF?
dc.typeArticle

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