Phenolic Content, Antioxidant Capacity, and Therapeutic Potential of Mango (Mangifera indica L.) Leaves

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Küçük Resim

Tarih

2025

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

John Wiley and Sons Inc

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The phenolic composition, antioxidant capacity, and enzyme inhibition activities of Mangifera indica L. leaf (MLs) ethanol extract were comprehensively evaluated to explore its therapeutic and industrial applications. Quantitative profiling of 21 phenolic compounds was performed using the LC–MS/MS method, with vanillic acid (1242.47 μg/L), gallic acid (283.58 μg/L), and quercetin (102.40 μg/L) identified as the most abundant constituents. Antioxidant activities were assessed through DPPH, ABTS, FRAP, and CUPRAC assays, revealing moderate radical scavenging (DPPH: 26.87% ± 2.25%, ABTS: 14.65% ± 1.83%) and metal reduction capacities (FRAP: 0.118 ± 0.07, CUPRAC: 0.172 ± 0.03). In addition, MLs extract demonstrated dose-dependent inhibitory effects on acetylcholinesterase (AChE, IC50: 18.73 μg/mL), butyrylcholinesterase (BChE, IC50: 8.56 μg/mL), and α-glucosidase (IC50: 10.83 μg/mL), highlighting its potential in the management of neurodegenerative diseases such as Alzheimer's and metabolic disorders including diabetes. The findings emphasize the bioactive potential of M. indica leaves, positioning them as a promising resource for sustainable valorization. By showcasing the applicability of this agricultural by-product, the study provides a foundation for innovations in the food, nutraceutical, and pharmaceutical sectors. Nevertheless, further in vivo and clinical investigations are essential to fully validate their safety and therapeutic efficacy.

Açıklama

Anahtar Kelimeler

Antidiabetic, Antioxidant, Enzyme Inhibition, Mangifera Indica L, Phenolic Composition

Kaynak

Food Science and Nutrition

WoS Q Değeri

Q2

Scopus Q Değeri

Cilt

13

Sayı

5

Künye