BODIPY and 2,3-dihydrophthalazine-1,4-dione conjugates as heavy atom-free chemiluminogenic photosensitizers
| dc.contributor.author | Değirmenci, Aysun | |
| dc.contributor.author | Sonkaya, Ömer | |
| dc.contributor.author | Soylukan, Caner | |
| dc.contributor.author | Karaduman, Tuğçe | |
| dc.contributor.author | Algı, Fatih | |
| dc.date.accessioned | 2021-11-02T06:36:53Z | |
| dc.date.available | 2021-11-02T06:36:53Z | |
| dc.date.issued | 2021 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | We disclose an interesting concept for developing heavy atom-free chemiluminogenic photosensitizers. To accomplish this, conjugates 2 and 3, which are composed of boron-dipyrromethene (BODIPY) and 2,3-dihydrophthalazine-1,4-dione units, are investigated. 2 and 3 are compared in terms of their photophysical properties, chemiluminescence responses, and singlet oxygen production. Strikingly, the results indicate that decoration of BODIPY with the 2,3-dihydrophthalazine-1,4-dione scaffold boosts the singlet oxygen generation. Furthermore, treatment of epidermoid laryngeal carcinoma Hep-2 (Hep-2) cells with conjugates 2 and 3 results in efficient cellular internalization which ensures live- cell imaging of Hep-2 cells. Finally, it is noteworthy that in vitro cytotoxicity assays reveal that both 2 and 3 induce cytotoxicity when illuminated with red light. Thus, 2 and 3 represent heavy atom-free chemiluminogenic photosensitizers. | |
| dc.identifier.doi | 10.1021/acsabm.1c00328 | |
| dc.identifier.endpage | 5098 | en_US |
| dc.identifier.issn | 2576-6422 | |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 5090 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1021/acsabm.1c00328 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8557 | |
| dc.identifier.volume | 4 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | tr | |
| dc.publisher | American Chemical Society | |
| dc.relation.ispartof | ACS Applied Bio Materials | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Photodynamic therapy (PDT) | |
| dc.subject | Heavy-atom Free Photosensitizer | |
| dc.subject | Chemiluminescence | |
| dc.subject | CRET | |
| dc.subject | BODIPY | |
| dc.title | BODIPY and 2,3-dihydrophthalazine-1,4-dione conjugates as heavy atom-free chemiluminogenic photosensitizers | |
| dc.type | Article |
