Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis

dc.authorid0000-0002-6543-8447
dc.authorid0000-0003-0999-2774
dc.authorid0000-0002-8488-6405
dc.authorid0000-0002-8488-6405
dc.authorid0000-0002-8919-968X
dc.authorid0000-0001-7531-3704
dc.authorid/0000-0002-7074-1694
dc.authorid0000-0002-9339-4031
dc.authorid0000-0002-0932-906X
dc.contributor.authorDoğaner, Fulya
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorTurgut Coşan, Didem
dc.contributor.authorÖzgen, Merih
dc.contributor.authorBerkan, Funda
dc.contributor.authorŞahin Mutlu, Fezan
dc.contributor.authorDeğirmenci, İrfan
dc.contributor.authorGüneş, Hasan Veysi
dc.date.accessioned2024-11-19T08:09:37Z
dc.date.available2024-11-19T08:09:37Z
dc.date.issued2024
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractOsteoporosis is a common age-related skeletal disease, characterized by changes in the microarchitectural structure of bone tissue and decreased bone mass, especially affecting postmenopausal women. Genetic and environmental factors affecting bone metabolism play a role in the development of osteoporosis. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in the conversion of homocysteine to methionine. Genetic variations in the MTHFR gene lead to impaired function or inactivation of this enzyme. A decrease in MTHFR enzyme activity and an increase in homocysteine levels affect bone metabolism. In this study, we aimed to investigate the relationship between C677T and A1298C polymorphisms and osteoporosis in Turkish postmenopausal women. DNA samples were extracted from 200 volunteers. The PCR-RFLP technique was used to identify the MTHFR gene polymorphisms C677T and A1298C. The statistical significance of the analysis’s results was assessed. C677T genotype and allele frequency distributions were not statistically different between postmenopausal osteoporosis and healthy control groups (p=0.249, p=0.754), while A1298C genotype and allele frequency distributions were found to be statistically significant (p=0.002, p=0.013). The results of our study showed that the A1298C polymorphism may be a genetic factor associated with osteoporosis in this specific population. However, the C677T polymorphism did not show a significant connection. To gain a more comprehensive understanding of the genetic basis of osteoporosis, future research with larger sample sizes and the consideration of additional genetic and environmental factors is essential. Additionally, it is crucial to account for ethnic disparities, gene-gene interactions, and gene-environment interplays. These insights can inform the development of personalized preventive and therapeutic strategies for individuals at risk of osteoporosis in diverse populations.
dc.identifier.doi10.1080/15257770.2024.2421302
dc.identifier.scopusqualityN/A
dc.identifier.urihttps:/dx.doi.org/10.1080/15257770.2024.2421302.
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12652
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofNucleosides, Nucleotides & Nucleic Acids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOsteoporosis
dc.subjectMTHFR
dc.subjectC677T
dc.subjectA1298C
dc.subjectPolymorphism
dc.titleMethylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis
dc.typeArticle

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