Gold nanoparticles loaded TNF-? and CALNN peptide as a drug delivery system and promising therapeutic agent for breast cancer cells

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dc.contributor.authorJabir, Majid S.
dc.contributor.authorAbood, Noor A.
dc.contributor.authorJawad, Marwa H.
dc.contributor.authorÖztürk, Kamile
dc.contributor.authorKadhim, Haider
dc.contributor.authorAlbukhaty, Salim
dc.contributor.authorAl-Shammari, Ahmed
dc.contributor.authorAlMalki, Faizah A.
dc.contributor.authorAlbaqami, Jawaher
dc.contributor.authorSulaiman, Ghassan M.
dc.date.accessioned2023-01-16T12:10:49Z
dc.date.available2023-01-16T12:10:49Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractWe investigated the anti-cancer properties of gold nanoparticles loaded TNF- and CALNN peptides, which we proposed as a potential drug delivery system using in vitro and in vivo models. The binding of GNPs-TNF- and GNPs-TNF-CALNN was characterized using a UV, ELISA and SEM analysis. The outcomes demonstrated that a novel drug delivery system had an anti-proliferative activity against breast cancer cell lines through a mechanism of apoptosis induction. In vivo model involved studying the cytotoxic influence of a drug delivery system GNPs, GNPs-TNF-? and GNPs-TNF-?-CALNN when applied to the transplanted AN-3 cell line. tumor sections were examined using microarray. In-vivo studies demonstrated that GNPs alone had less of a growth inhibitory effect on tumors implanted in mice when compared to GNPs-TNF–CALNN combined therapy. The cytotoxic assay showed that GNPs, GNPs-TNF-? and GNPs-TNF-?-CALNN exhibit selective toxicity towards cancer cells, inducing cell apoptosis through activation of caspase-3 and 7, p53 protein.
dc.identifier.doi10.1080/10667857.2022.2133073
dc.identifier.endpage3166en_US
dc.identifier.issn1066-7857
dc.identifier.issue14en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage3152en_US
dc.identifier.urihttps:/dx.doi.org/10.1080/10667857.2022.2133073
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9943
dc.identifier.volume37en_US
dc.identifier.wosWOS:000867615300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofMaterials Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApoptosis
dc.subjectBreast Cancer
dc.subjectCALNN
dc.subjectGold Nanoparticles
dc.subjectTNF- ?
dc.titleGold nanoparticles loaded TNF-? and CALNN peptide as a drug delivery system and promising therapeutic agent for breast cancer cells
dc.typeArticle

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