Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway

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dc.authoridAslan, Abdullah -- 0000-0002-6243-4221
dc.contributor.authorAslan, Abdullah
dc.contributor.authorCan, Muhammed İsmail
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:52Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:52Z
dc.date.issued2014
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractAim: The objective of this study was to examine whether MT plays a protective role against the damage in the liver by administering carbontetrachloride (CCl4) to rats. Main method: 28 male Wistar albino (n = 28, 8 weeks old) rats have been used in the study. The rats were distributed into 4 groups according to their live weights. The groups were: (i) negative control (NC): normal water consuming group to which no CCl4 and milk thistle (MT) is administered; (ii) positive control (PC): normal water consuming group to which no Cat is administered but MT is administered; (iii) CCl4 group: normal water consuming and group to which CCl4 is administered (2 ml/kg live weight, ip); and (iv) CCl4 + MT group: CCl4 and MT administered group (2 ml/kg live weight. ip). Caspase-3, caspase-9, bax, and bcl-2 protein syntheses were examined via western blotting. MDA determination in liver tissue was made using spectrophotometer. Key findings: MDA amount has decreased in the CCl4 + MT group in comparison to CCl4 group whereas caspase-3 and caspase-9 has increased and bax and bcl-2 has decreased. Significance: These results show that MT protects the liver against oxidative damage.
dc.description.sponsorshipFirat University Scientific Research Projects Unit (FUBAP) [FF.13.19]
dc.description.sponsorshipThe article supported by Firat University Scientific Research Projects Unit (FUBAP) with FF.13.19 project number. Some results of this article were presented at the 22nd National Biology Meeting (2014), Eskisehir, Turkey.
dc.identifier.doi10.1016/j.lfs.2014.09.005
dc.identifier.endpage18en_US
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.issue1en_US
dc.identifier.pmid25305509
dc.identifier.scopusqualityQ1
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2014.09.005
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5730
dc.identifier.volume117en_US
dc.identifier.wosWOS:000345196900003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE
dc.relation.ispartofLIFE SCIENCES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMilk Thistle
dc.subjectLiver Damage
dc.subjectCaspase-3
dc.subjectCaspase-9
dc.subjectBax
dc.subjectBcl-2
dc.titleMilk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway
dc.typeArticle

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