Apoptotic effects of dipyrido [3,2-a:2 ',3 '-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats

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dc.authoridÖzbayer, Cansu -- 0000-0002-1120-1874; Benkli, Kadriye -- 0000-0002-9042-8718
dc.contributor.authorTekin, Neslihan
dc.contributor.authorÜstüner, Mehmet Cengiz
dc.contributor.authorAkyüz, Fahrettin
dc.contributor.authorÖzbayer, Cansu S.
dc.contributor.authorAydın, Ozlem
dc.contributor.authorBenkli, Kadriye
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorDeğirmenci, İrfan
dc.contributor.authorÖzden, Hilmi
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:28Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:28Z
dc.date.issued2014
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractWe evaluated the effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl-2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six groups; group I (control), group II [Dimethyl sulfoxide (DMSO)], group III ([Au(dppz)Cl-2]Cl), group IV [diethylnitrosamine + Phenobabital (DEN + PB)], group V (DEN + PB + [Au(dppz)Cl-2]Cl (2nd week)), and group VI (DEN + PB + [Au(dppz)Cl-2]Cl (7th week). The rats in groups IV through VI were administrated with DEN in a single dose of intraperitoneal 175 mg/kg. After 2 weeks of DEN administration, these groups of rats were given daily PB in a dose of 500 ppm. In group V, after two weeks of DEN administration, [Au(dppz)Cl-2]Cl complex (2 mg/kg) was given once a week by intraperitoneal injection. In the group VI, the rats were given a dose of 2 mg/kg [Au(dppz)Cl-2]Cl complex once a week, 7 weeks after DEN administration. At the end of the study, blood and tissue samples were collected from the rats to determine levels of serum AST, ALT, and LDH, and caspase 3, p53, Bax, Bcl-2 and DNA fragmentation in liver. AST, ALT, LDH, and Bcl-2 levels were higher in group IV, compared to group I, but caspase 3 and p53 levels were lower. In group V, caspase 3, p53, Bax, and DNA fragmentation levels were higher than those of group IV. Caspase 3 and p53 levels increased in group VI compared with group IV. In conclusion, [Au(dppz)Cl-2]Cl complex induced apoptosis by elevating levels of caspase 3, p53, Bax, and DNA fragmentation.
dc.description.sponsorshipEskisehir Osmangazi University Scientific Research Commission [201011044]
dc.description.sponsorshipThis study was supported by Eskisehir Osmangazi University Scientific Research Commission. Contract grants number 201011044.
dc.identifier.doi10.1007/s11033-014-3376-2
dc.identifier.endpage5121en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue8en_US
dc.identifier.pmid24756331
dc.identifier.scopusqualityQ2
dc.identifier.startpage5109en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-014-3376-2
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6278
dc.identifier.volume41en_US
dc.identifier.wosWOS:000339910900026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGold(III) Complexes
dc.subjectApoptosis
dc.subjectBax
dc.subjectBcl-2
dc.subjectCaspase 3
dc.titleApoptotic effects of dipyrido [3,2-a:2 ',3 '-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats
dc.typeArticle

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