Autologous platelet-rich plasma treatment in a dog with vincristine extravasation injury

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dc.authorid0000-0001-7039-8956
dc.contributor.authorBoztok Özgermen, Başak
dc.date.accessioned2023-10-02T10:31:31Z
dc.date.available2023-10-02T10:31:31Z
dc.date.issued2023
dc.departmentVeteriner Fakültesi
dc.description.abstractExtravasation of vincristine sulfate (VS) is a common complication encountered during canine transmissible venereal tumor treatment and other hematopoietic neoplasms, such as lymphoma and leukemias. The leakage of the chemotherapeutic agent may result in soft tissue damage leading to ulceration and necrosis. Studies have shown that platelet-rich plasma consists of growth factors and cytokines, thus plays a crucial role in wound healing. This study aimed to evaluate the effects of autologous platelet-rich plasma and antimicrobial wound dressing for the treatment of VS extravasation-related acute full-thickness skin wounds. A male Aksaray Malakli shepherd dog (3 years old) was brought to our clinic with a wound on the left forelimb which appeared two days after intravenous injection of VS. Extravasation was suspected. A total of 3.5 mL autologous platelet-rich plasma was injected into the wound margins and an antimicrobial dressing containing chlorhexidine acetate was used weekly to close the wound. The wound healed without any complications in 6 weeks. It was concluded that autologous platelet-rich plasma treatment is a simple and cost-effective method for the treatment of VS extravasation-related acute full-thickness skin wounds.
dc.identifier.doi10.1556/004.2023.00730
dc.identifier.endpage29en_US
dc.identifier.issn0236-6290
dc.identifier.issue1en_US
dc.identifier.pmid37171916
dc.identifier.scopusqualityQ2
dc.identifier.startpage25en_US
dc.identifier.urihttps:/dx.doi.orgDOI 10.1556/004.2023.00730
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11033
dc.identifier.volume71en_US
dc.identifier.wosWOS:001027645200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofActa veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDog
dc.subjectExtravasation
dc.subjectPlatelet-rich Plasma
dc.subjectVincristine
dc.subjectWound Healing
dc.titleAutologous platelet-rich plasma treatment in a dog with vincristine extravasation injury
dc.typeArticle

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