Evaluation of the protective effects of morin against acrylamide-induced lung toxicity by biomarkers of oxidative stress, inflammation, apoptosis, and autophagy

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dc.authorid0000-0002-9151-4124
dc.authorid0000-0003-0840-2613
dc.authorid0000-0001-5367-0743
dc.authorid0000-0003-4039-3497
dc.authorid0000-0002-7174-3448
dc.contributor.authorYeşildağ, Kerim
dc.contributor.authorEröz, Recep
dc.contributor.authorGenç, Aydın
dc.contributor.authorDoğan, Tuba
dc.contributor.authorSatıcı, Emine
dc.date.accessioned2022-02-24T06:19:16Z
dc.date.available2022-02-24T06:19:16Z
dc.date.issued2022
dc.departmentTıp Fakültesi
dc.description.abstractAcrylamide (ACR) has genotoxic, neurotoxic, and carcinogenic effects. From past to present, various plants or their products have been used for therapeutic purposes such as morin. It was aimed to detect possible protective effects of morin vs ACR-induced lung toxicity. The rats, treated with ACR alone or with morin for 10 consecutive days, were included in the study. A broad variety of biomarkers related to oxidative stress, apoptosis, autophagy, and inflammatory responses were evaluated. ACR increased malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-?), cyclooxygenase-2 (COX-2), nuclear factor kappa-B (NF-?B), Beclin-1, IL-1?, bcl-2 associated X protein (Bax), caspase-3, light chain 3-A (LC3-A), and light chain 3-B (LC3-B) levels but reduced mammalian target of rapamycin (mTOR), b-cell lymphoma-2 (Bcl-2), catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH) in lung tissues. The morin had effects on the level of these molecules in a way that is opposite to ACR. While ACR-induced oxidative stress, apoptotic, autophagic, inflammatory responses, and may cause pulmonary dysfunction, the morin reduced ACR-induced lung damage. Practical applications: ACR is a toxic chemical produced by frying, baking, roasting, or grilling foods with high starch content and has genotoxic, neurotoxic, and carcinogenic effects. As an antioxidant compound, the morin is obtained from plants or their products. It was aimed to detect possible protective effects of morin against ACR-induced lung toxicity. It was detected that ACR-induced oxidative stress, apoptotic, autophagic, inflammatory responses, and may cause pulmonary dysfunction, but the morin reduced ACR-induced lung damage.
dc.identifier.doi10.1111/jfbc.14111
dc.identifier.endpage-en_US
dc.identifier.issn0145-8884
dc.identifier.issue-en_US
dc.identifier.pmid35156211
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1111/jfbc.14111
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9221
dc.identifier.volume-en_US
dc.identifier.wosWOS:000762667200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAcrylamide
dc.subjectApoptosis
dc.subjectLung Toxicity
dc.subjectMorin
dc.titleEvaluation of the protective effects of morin against acrylamide-induced lung toxicity by biomarkers of oxidative stress, inflammation, apoptosis, and autophagy
dc.typeArticle

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