A novel proton transfer salt of 2-amino-6-sulfamoylbenzothiazole and its metal complexes: the evaluation of their inhibition effects on human cytosolic carbonic anhydrases

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dc.contributor.authorAlkaya, Zeynep Alkan
dc.contributor.authorİlkimen, Halil
dc.contributor.authorYenikaya, Cengiz
dc.contributor.authorKaygısız, Yasemin
dc.contributor.authorBülbül, Metin
dc.contributor.authorTunç, Tuncay
dc.contributor.authorSarı, Musa
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:09Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:09Z
dc.date.issued2017
dc.departmentEğitim Fakültesi
dc.description.abstractA novel proton transfer compound (SMHABT) (+)(HDPC)(-) (1) obtained from 2-amino-6-sulfamoylbenzothiazole (SMABT) and 2,6-pyridinedicarboxylic acid (H2DPC) and its Fe(III), Co(II), Ni(II) complexes (2-4), and Fe(II) complex of SMABT (5) have been prepared and characterized by spectroscopic techniques. Additionally, single crystal X-ray diffraction techniques were applied to complexes (2-4). All complexes (2-4) have distorted octahedral conformations and the structure of 5 might be proposed as octahedral according to spectral and analytical results. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human hCA I and hCA II for their hydratase and esterase activities. The synthesized compounds have remarkable inhibitory activities on hCA I and hCA II. Especially, the inhibition potentials of the salt and the metal complexes (1-5) are comparable with AAZ. Inhibition data have been analyzed by using a one-way analysis of variance for multiple comparisons (p < .0001).
dc.description.sponsorshipDumlupinar University Research Fund [2014/18]
dc.description.sponsorshipThis work was supported by the Dumlupinar University Research Fund [(grant No. 2014/18)].
dc.identifier.doi10.1080/14756366.2016.1247058
dc.identifier.endpage239en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue1en_US
dc.identifier.pmid28100079
dc.identifier.scopusqualityQ1
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1080/14756366.2016.1247058
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6245
dc.identifier.volume32en_US
dc.identifier.wosWOS:000392591100016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarbonic Anhydrase
dc.subjectMetal Complex
dc.subjectProton Transfer
dc.subjectStatistical Analyses
dc.subject2-amino-6-sulfamoylbenzothiazole
dc.subject2,6-pyridinedicarboxylic acid
dc.titleA novel proton transfer salt of 2-amino-6-sulfamoylbenzothiazole and its metal complexes: the evaluation of their inhibition effects on human cytosolic carbonic anhydrases
dc.typeArticle

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