Genetic diversity of disease-associated loci in Turkish population

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dc.authoridPolimanti, Renato -- 0000-0003-0745-6046
dc.contributor.authorKaraca, Şefayet
dc.contributor.authorCesuroğlu, Tomris
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorErge, Sema
dc.contributor.authorPolimanti, Renato
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:29:29Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:29:29Z
dc.date.issued2015
dc.departmentSağlık Bilimleri Fakültesi
dc.description.abstractMany consortia and international projects have investigated the human genetic variation of a large number of ethno-geographic groups. However, populations with peculiar genetic features, such as the Turkish population, are still absent in publically available datasets. To explore the genetic predisposition to health-related traits of the Turkish population, we analyzed 34 genes associated with different health-related traits (for example, lipid metabolism, cardio-vascular diseases, hormone metabolism, cellular detoxification, aging and energy metabolism). We observed relevant differences between the Turkish population and populations with non-European ancestries (that is, Africa and East Asia) in some of the investigated genes (that is, AGT, APOE, CYP1B1, GNB3, IL10, IL6, LIPC and PON1). As most complex traits are highly polygenic, we developed polygenic scores associated with different health-related traits to explore the genetic diversity of the Turkish population with respect to other human groups. This approach showed significant differences between the Turkish population and populations with non-European ancestries, as well as between Turkish and Northern European individuals. This last finding is in agreement with the genetic structure of European and Middle East populations, and may also agree with epidemiological evidences about the health disparities of Turkish communities in Northern European countries.
dc.description.sponsorshipGENAR Institute for Public Health and Genomics Research
dc.description.sponsorshipWe are greatly indebted to Dr Serdar Savas, the founder of the GENAR Public Health and Genomics Research Institute, for his great contribution to the development of the Gentest Model and its components. We would also like to thank to Marco De Langen, as well as all the staff members of the GENAR Molecular Biology and Genetics Research and Application Laboratories for their contributions. This research was funded through a grant from the GENAR Institute for Public Health and Genomics Research.
dc.identifier.doi10.1038/jhg.2015.8
dc.identifier.endpage198en_US
dc.identifier.issn1434-5161
dc.identifier.issn1435-232X
dc.identifier.issue4en_US
dc.identifier.pmid25716910
dc.identifier.scopusqualityQ1
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1038/jhg.2015.8
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6173
dc.identifier.volume60en_US
dc.identifier.wosWOS:000353565700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofJournal of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleGenetic diversity of disease-associated loci in Turkish population
dc.typeArticle

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