Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N?-Nitro-L-arginine methyl ester
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by N?-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P<0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P<0.05). L-NAME caused increase (P<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P<0.05), platelets and lymphocyte increased (P<0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.
Description
PubMed ID: 24035946
Keywords
Biochemical Parameter, Blood, Hematological Parameter, L-NAME, Propolis, Rat
Journal or Series
Pakistan Journal of Pharmaceutical Sciences
WoS Q Value
N/A
Scopus Q Value
Q3
Volume
26
Issue
5
