Amphibian egg jelly as a biocompatible material: physicochemical characterization and selective cytotoxicity against melanoma cells

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dc.authorid0000-0002-6761-8011
dc.authorid0000-0001-6054-8842
dc.authorid0000-0002-0372-7462
dc.contributor.authorKoç Bilican, Behlül
dc.contributor.authorKaraduman Yeşildal, Tuğçe
dc.contributor.authorTornacı, Selay
dc.contributor.authorCansaran Duman, Demet
dc.contributor.authorÖner, Ebru Toksoy
dc.contributor.authorGül, Serkan
dc.contributor.authorKaya, Murat
dc.date.accessioned2025-09-18T05:56:49Z
dc.date.available2025-09-18T05:56:49Z
dc.date.issued2025
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractExtensive research on amphibians has focused on areas such as morphological and molecular taxonomy, ecology, embryology, and molecular phylogeny. However, the structure and biotechnological potential of egg jelly—which plays a protective and nutritive role for embryos—have remained largely unexplored. This study presents, for the first time, a detailed physicochemical analysis of the egg jelly of Pelophylax ridibundus, an amphibian species, using Fourier Transform Infrared Spectroscopy, Thermogravimetric Analyzer, X-ray Diffraction, and elemental analysis. The carbohydrate content was determined via High-Performance Liquid Chromatography analysis, and the protein content was identified using Liquid Chromatography-Tandem Mass Spectrometry analysis. Additionally, it was revealed that this jelly exhibits a significant cytotoxic effect on melanoma cells (viability < 30%) while showing no cytotoxicity on healthy dermal fibroblast cells (viability > 70%). Consequently, this non-toxic, biologically derived, and cultivable material is proposed as a promising candidate for cancer applications, paving the way for further research in the field.
dc.identifier.doi10.3390/polym17152046
dc.identifier.issn20734360
dc.identifier.issue15
dc.identifier.scopus2-s2.0-105013200602
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym17152046
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14448
dc.identifier.volume17
dc.identifier.wosWOS:001550659600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKoç Bilican, Behlül
dc.institutionauthorKaraduman Yeşildal, Tuğçe
dc.institutionauthorid0000-0001-9943-771X
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofPolymersMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmphibian Egg Jelly
dc.subjectAnticancer
dc.subjectBiocompatible Material
dc.subjectMelanoma
dc.subjectPelophylax Ridibundus
dc.subjectReal-Time Cell Analysis
dc.titleAmphibian egg jelly as a biocompatible material: physicochemical characterization and selective cytotoxicity against melanoma cells
dc.typeArticle

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