The role of serum netrin-1 level in the detection of early-onset preeclampsia
| dc.contributor.author | Soykan Sert, Zekiye | |
| dc.date.accessioned | 2022-02-23T10:22:23Z | |
| dc.date.available | 2022-02-23T10:22:23Z | |
| dc.date.issued | 2022 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Objective: To investigate whether serum netrin-1 levels measured in hypertensive pregnant women could predict the development of early-onset preeclampsia (EOP). Methods: This prospective observational study was conducted at a single academic medical center between August 1, 2019, and July 31, 2021. The study included patients aged >18 years who presented to our clinic because of gestational hypertension at gestational weeks 20–24 and underwent serum netrin-1 level measurements. All the patients were followed up until delivery for the development of preeclampsia. The patients were divided into two subgroups: those who developed EOP and those who developed late-onset preeclampsia (LOP). Results: Ninety-seven patients and 45 healthy controls were included in the study. EOP and LOP developed in 43 (44.3%) and 54 (55.7%) of the patients, respectively. The mean serum netrin-1 level at the time of presentation was significantly higher in the EOP group than in the control group (916.8 ± 370.5 pg/mL vs 487.7 ± 220.4 pg/mL; p [removed]784.9 pg/mL predicted the development of EOP with a sensitivity of 72.0% (95% CI: 56.3–84.7%) and specificity of 88.8% (95% CI: 75.9–96.3%). Conclusion: High serum netrin-1 levels were significantly associated with the development of EOP. The initial serum netrin-1 level may be useful for determining the risk of developing EOP in women with gestational hypertensive disorder. | |
| dc.identifier.doi | 10.1016/j.ejogrb.2022.01.010 | |
| dc.identifier.endpage | 168 | en_US |
| dc.identifier.issn | 0301-2115 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.pmid | 35063900 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 164 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1016/j.ejogrb.2022.01.010 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/9212 | |
| dc.identifier.volume | 270 | en_US |
| dc.identifier.wos | WOS:000774443600020 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Ireland Ltd | |
| dc.relation.ispartof | Elsevier Ireland Ltd | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Early-onset Preeclampsia | |
| dc.subject | Late-onset Preeclampsia | |
| dc.subject | Netrin-1 | |
| dc.subject | Pregnancy | |
| dc.title | The role of serum netrin-1 level in the detection of early-onset preeclampsia | |
| dc.type | Article |
