Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line

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dc.authoridKAVAZ, DOGA -- 0000-0003-1503-1689
dc.contributor.authorAkbal, Öznur
dc.contributor.authorErdal, Ebru
dc.contributor.authorVural, Tayfun
dc.contributor.authorKavaz, Do?a
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:32Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:32Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen-Edebiyat Fakültesi
dc.description.abstractIn this study, human serum albumin (HSA) was used as a protein-based material and poly (3-hydroxybutyrate) (PHB)-carboxymethyl chitosan (CMCh) as a polysaccharide-based material for the production of nanoparticles to be used as nanocarriers in cancer therapy. HSA and PHB-CMCh nanoparticles were prepared and characterized with a Zeta Sizer, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscope. The effects of the pH value of the suspending medium and the amounts of crosslinker and polymer concentration on nanoparticle size and size distribution were investigated. The anticancer-agent etoposide was used as a model drug and encapsulated in nanoparticles to obtain drug release profiles. The entrapment efficiency of HSA nanoparticles was found to be greater than that of PHB-CMCh nanoparticles. To achieve "active'' targeting of cancer cells, the nanoparticles were modified with concanavalin A. In the final step of the study, the interaction of nanoparticles with cancer cells was investigated in cytotoxicity and cellular uptake studies.
dc.identifier.doi10.3109/21691401.2016.1170694
dc.identifier.endpage203en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue2en_US
dc.identifier.pmid27087191
dc.identifier.scopusqualityQ1
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2016.1170694
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5884
dc.identifier.volume45en_US
dc.identifier.wosWOS:000394596500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofArtificial Cells, Nanomedicine, and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectConcanavalin A
dc.subjectEtoposide
dc.subjectHSA Nanoparticle
dc.subjectPHB-CMCh Nanoparticle
dc.titleComparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line
dc.typeArticle

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