Investigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder

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dc.contributor.authorYazıcı, Merve
dc.contributor.authorYektaş, Çiğdem
dc.contributor.authorEröz, Recep
dc.contributor.authorKaplan Karakaya
dc.contributor.authorElif Sümeyra
dc.contributor.authorSarıgedik, Enes
dc.date.accessioned2023-01-23T06:17:38Z
dc.date.available2023-01-23T06:17:38Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractObjective: It was aimed to investigate the role of the forkhead box protein P2 (FOXP2) gene in the cause of specific learning disorder (SLD) with the next-generation sequencing method. Material and methods: The study included 52 children diagnosed with SLD and 46 children as control between the ages of 6-12 years. Interview Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifelong Version in Turkish, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-Based Screening and Evaluation Scale for Attention Deficit and Disruptive Behavior Disorders, Specific Learning Disability Test Battery were applied to all participants. The FOXP2 gene was screened by the next-generation sequencing (NGS) method in all participants. Results: A total of 17 variations were detected in the FOXP2 gene in participants. The number and diversity of variations were higher in the patient group. In the patient group, c.1914 + 8A>T heterozygous variation and three different types of heterozygous variation (13insT, 13delT and 4dup) in the c.1770 region were detected. It was found that the detected variations showed significant relationships with the reading phenotypes determined by the test battery. Conclusion: It was found that FOXP2 variations were seen more frequently in the patient group. Some of the detected variations might be related to the clinical phenotype of SLD and variations found in previous studies from different countries were not seen in Turkish population. Our study is the first to evaluate the role of FOXP2 gene variations in children with SLD in Turkish population, and novel variations in the related gene were detected.
dc.identifier.doi10.1097/YPG.0000000000000326
dc.identifier.endpage19en_US
dc.identifier.issue1en_US
dc.identifier.pmid36617742
dc.identifier.scopusqualityQ3
dc.identifier.startpage8en_US
dc.identifier.urihttps:/dx.doi.org/10.1097/YPG.0000000000000326
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10001
dc.identifier.volume33en_US
dc.identifier.wosWOS:000910514400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer
dc.relation.ispartofPsychiatric Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDyslexia
dc.subjectFOXP2 Gene
dc.subjectNext-Generation Sequence Analysis
dc.subjectSpecific Learning Disorder Test Battery
dc.subjectSpecific Learning Disorde
dc.titleInvestigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder
dc.typeArticle

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